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Endothelial cell-specific knockout of ATG5 ameliorates inflammation and renal fibrosis by regulating pyroptosis
Objectives: ATG5, a key regulator of autophagy-associated inflammation, is markedly upregulated under inflammatory conditions. In this study, we observed significantly elevated ATG5 expression in the kidneys of patients with renal fibrosis and in mouse …
Publication
Aortic asprosin overexpression does not ameliorate disease pathophysiology in a murine model of Marfan syndrome
Marfan syndrome (MFS) is a connective tissue disorder caused by FBN1 mutations, characterised by aortic aneurysms leading to life-threatening dissections. Asprosin is the C-terminal propeptide of fibrillin-1 that was shown to function as a glucogenic …
Publication
Time-Series Analysis of Pregnancy and Childbirth Effects on Pelvic Floor Muscle Electrophysiology and Morphology in Rats
Introduction and Hypothesis: This study examined the differential effects of pregnancy and parturition on electrophysiological and histomorphometric properties in rat pelvic floor muscle (PFM) groups to provide a theoretical basis for targeted electrical …
Publication
Contrast-enhanced ultrasound and photoacoustic imaging to assess early and late renal ischemia-reperfusion injuries in male mice
Tissue perfusion and oxygenation, key factors of renal ischemia-reperfusion injury (RIR), can be assessed using contrast-enhanced ultrasound (CEUS) and photoacoustic (PA) imaging. We hypothesized that early changes in renal perfusion and oxygenation …
Publication
Aortic Segments-Depending Hypertensive Remodeling Is Driven by Mitochondrial Fusion Dysfunction
OPA1 haploinsufficiency exacerbates severe hypertension-induced aortic remodeling in a segment-specific manner, revealing differential vulnerability between the suprarenal abdominal aorta (SRAA) and the descending thoracic aorta (DTA). In the SRAA, …
Publication
Protocol for inducing deep vein thrombosis in C57BL/6J mice using the inferior vena cava stenosis model
Here, we present a protocol for inducing deep vein thrombosis (DVT) in C57BL/6J mice using the inferior vena cava (IVC) stenosis model. We describe steps for surgical preparation, IVC ligation, and non-invasive detection and confirmation of thrombus …
Publication
Theaflavin alleviates thoracic aortic dissection by disrupting the interaction between microtubule affinity-regulating kinase 4 and NLRP3 to inhibit inflammasome assembly
Theaflavin alleviates thoracic aortic dissection by disrupting the interaction between microtubule affinity-regulating kinase 4 and NLRP3 to inhibit inflammasome …
Publication
Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1
Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1 …
Publication
Luteolin decreases sFlt-1 and mean arterial pressure in the RUPP animal model of placental ischemia
Objectives: Preeclampsia (PE) is a complication of pregnancy and a leading cause of maternal and fetal morbidity and mortality. Despite being prevalent and highly morbid, there are no approved treatments to relieve PE signs and symptoms. Many studies have …
Publication
Machine-intelligent multimodal algebot for intracavitary chemotherapy
Intracavitary drug instillation is a crucial therapeutic strategy for treating bladder cancer. However, current methods are limited in efficacy due to insufficient tumour targeting and drug penetration across tissue barriers in pathophysiological …