4D-Mode Imaging
Seeing More Matters - Capture the Entire Heart in Motion!

Bringing Together Dynamic Motion and 3D Geometry!

Quantify ejection fraction and fractional shortening with more accuracy than traditional echocardiography, and faster than cardiac MRI!

4D-Mode Imaging from FUJIFILM VisualSonics

4D imaging on the Vevo F2 represents the next step in the evolution of preclinical imaging; a feature that brings together the dynamic motion of the myocardium throughout the cardiac cycle with the 3D geometry of the heart.

4D ultrasound is the perfect solution for models that create abnormalities in the traditional geometric proportions of the heart such as:

  • Myocardial infarction
  • Congenital heart defects
  • Various genetic knockout models

For infarct researchers – calculate accurate chamber volumes throughout infarct progression quickly and easily.

What is 4D Imaging?

3D – High Spatial resolution - seeing the heart from any angle + 
EKV – High temporal resolution – seeing the entire cardiac cycle

 

  • Acquire a 3D image at every time-point of the cardiac cycle
  • Allows you to see the dynamics of the entire chamber or blood vessel
  • Acquisition in 4D-Mode is intuitive and easy to use!

What can you do with 4D Images?

Measurements you can obtain without making any assumptions about the shape or dynamics of the heart:

  • Cardiac function (ejection fraction, fractional shrtening, cardiac output)
  • Area changes
  • Linear measurements on individual frames
  • Volumetric changes (across all time-points in the cardiac cycle)
Essential Links

4D Imaging Gallery

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Mouse Abdominal Aorta in 4D

The mouse abdominal aorta imaged in 4D from a longitudinal view.

Cardiac Hypertrophy in 4D

A model of murine cardiac hypertrophy imaged using 4D.

Image courtesy of Dr. Craig Goergen, Purdue University. 

Left-Ventricular Myocardial Hypertrophy in 4D

4D image of mouse left ventricle (long and short axis views), displaying evident myocardial hypertrophy.​

4D Image of the Mouse Left Ventricle

4D image of the mouse left ventricle, acquired from a parasternal short axis view.

4D Image of the Mouse Right Atrium

4D image of the right atrium in a mouse.

4D Image of the Mouse Left Ventricle

4D image of the mouse left ventricle, acquired from a parasternal long axis view.

4D Image of the Mouse Left Atrium

4D image of the left atrium in a mouse.

4D Left Ventricular Volume Overlay

4D image of the mouse left ventricle acquired from a parasternal short axis view. A 4D volume was drawn and can be visualized in red.

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4D Publications

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TOP PAPER
Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction
Cardiovascular Ultrasound
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TOP PAPER
Sex differences in the evolution of left ventricle remodeling in rats with severe volume overload
BMC Cardiovascular Disorders
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TOP PAPER
Three-dimensional myocardial strain correlates with murine left ventricular remodelling severity post-infarction
Journal of The Royal Society Interface
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TOP PAPER
Strain Mapping From Four-Dimensional Ultrasound Reveals Complex Remodeling in Dissecting Murine Abdominal Aortic Aneurysms
Journal of Biomechanical Engineering
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TOP PAPER
Accurate and noise insensitive strain mapping enables ultrasound analysis of cardiac function in three dimensions
Journal of Biomechanical Engineering
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TOP PAPER
4D cardiac magnetic resonance imaging, 4D and 2D transthoracic echocardiography: a comparison of in-vivo assessment of ventricular function in rats
Laboratory Animals
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TOP PAPER
Evaluation of a commercial multi-dimensional echocardiography technique for ventricular volumetry in small animals
Cardiovascular Ultrasound
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High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function
Tomography
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