Bringing Together Dynamic Motion and 3D Geometry!
Quantify ejection fraction and fractional shortening with more accuracy than traditional echocardiography, and faster than cardiac MRI!
4D imaging - the next step in the evolution of preclinical echocardiography! Visualize the dynamic motion of the myocardium throughout the cardiac cycle with the 3D geometry of the heart.
4D ultrasound is the perfect solution for cardiac disease models that create abnormalities in the traditional geometric proportions of the heart such as:
- Myocardial infarction - calculate accurate chamber volumes throughout infarct progression
- Congenital heart defects
- Various genetic knockout models
What is 4D Imaging?
3D – High Spatial resolution - seeing the heart from any angle +
EKV – High temporal resolution – seeing the entire cardiac cycle
- Acquire a 3D image at every time-point of the cardiac cycle
- Acquisition in 4D-Mode is intuitive and easy to use!
What can you do with 4D Images?
Combine 4D with Color or Power Doppler on the Vevo F2 for unprecedented visualization of cardiac flow dynamics!
Measurements you can obtain without making any geometric assumptions about the heart:
- Cardiac function (ejection fraction, fractional shortening, cardiac output)
- Area changes
- Volumetric changes
4D Imaging Gallery

4D Image of the Mouse Left Ventricle
4D image of the mouse left ventricle, acquired from a parasternal long axis view.

4D Image of the Mouse Left Atrium
4D image of the left atrium in a mouse.

4D Left Ventricular Volume Overlay
4D image of the mouse left ventricle acquired from a parasternal short axis view. A 4D volume was drawn and can be visualized in red.

Parasternal Long Axis in Color 4D


Cardiac Hypertrophy in 4D
A model of murine cardiac hypertrophy imaged using 4D.
Image courtesy of Dr. Craig Goergen, Purdue University.

Left-Ventricular Myocardial Hypertrophy in 4D
4D image of mouse left ventricle (long and short axis views), displaying evident myocardial hypertrophy.

4D Image of the Mouse Left Ventricle
4D image of the mouse left ventricle, acquired from a parasternal short axis view.

4D Image of the Mouse Right Atrium
4D image of the right atrium in a mouse.

4D Image of the Mouse Left Ventricle
4D image of the mouse left ventricle, acquired from a parasternal long axis view.

4D Image of the Mouse Left Atrium
4D image of the left atrium in a mouse.

4D Left Ventricular Volume Overlay
4D image of the mouse left ventricle acquired from a parasternal short axis view. A 4D volume was drawn and can be visualized in red.

Parasternal Long Axis in Color 4D


Cardiac Hypertrophy in 4D
A model of murine cardiac hypertrophy imaged using 4D.
Image courtesy of Dr. Craig Goergen, Purdue University.

Left-Ventricular Myocardial Hypertrophy in 4D
4D image of mouse left ventricle (long and short axis views), displaying evident myocardial hypertrophy.

4D Image of the Mouse Left Ventricle
4D image of the mouse left ventricle, acquired from a parasternal short axis view.

4D Image of the Mouse Right Atrium
4D image of the right atrium in a mouse.

4D Image of the Mouse Left Ventricle
4D image of the mouse left ventricle, acquired from a parasternal long axis view.

4D Image of the Mouse Left Atrium
4D image of the left atrium in a mouse.

4D Left Ventricular Volume Overlay
4D image of the mouse left ventricle acquired from a parasternal short axis view. A 4D volume was drawn and can be visualized in red.