Characterize, Visualize and Analyze your Molecular Contrast Agents with Photoacoustics
Exogenous contrast agents are important tools in a variety of imaging modalities including fluorescence, PET/SPECT, CT, MRI and ultrasound for visualizing cellular and molecular processes.
Furthermore, they can be used for diagnosis and treatment of a variety of diseases. Some of these agents are approved for clinical use and thus are ideal for translational research.
Molecular imaging with the Vevo F2 LAZR-X Photoacoustic Imaging System offers several advantages over other modalities:
- Deep optical signals visible with high-resolution (down to 40 μm) in real time
- Multispectral acquisition for imaging multiple components simultaneously (blood, exogenous contrast agents, genetic reporters)
- Non-invasive and non-ionizing
- Fusion of molecular data with detailed anatomical images
Types of Photoacoustic Contrast Agents
Nano-scale materials are increasingly used as molecular imaging agents for photoacoustics due to their very high absorption of light in the NIR range and their customizability in terms of size and surface chemistry.
Small molecular dyes are used extensively for in vivo fluorescence imaging as well as in microscopy for identifying cellular and molecular processes.
Danielle Charron highlights how a lot of the work they do in fluorescent imaging can also be done using photoacoustics as well.
This publication highlights the use of melanin and multi-wavelength photoacoustic imaging of inducible tyrosinase reporter gene expression in xenograft tumors.
AngiostampTM 800 is an organic near-infrared (NIR) fluorescent and photoacoustic imaging agent licensed by Optimal Grenoble, a small animal imaging team in France.