MSK
See changes in tissue and vascular structure in 2D & 3D
Ultrasound for In Vivo Assessment of Rheumatoid Arthritis
How much inflammation is in the arthritic joints? Assess the musculoskeletal system with Vevo technology!
Rapid, completely non-invasive visualization of the arthritic joint.
Using ultra-high frequency ultrasound and photoacoustics, visualize changes in tissue and vascular structure in 2D and 3D with resolution down to 30 microns, in vivo. Tissue oxygenation, capillary function, tissue inflammation, bone erosion and more can be assessed longitudinally without interfering with your experiment.
- Detect early onset of arthritis in drug-induced or spontaneous mouse models
- Assess levels of inflammation
- 3D reconstruction of joints
- Perform image guided injections (e.g. into the knee)
- Detect hemoglobin and oxygenation levels with the Vevo LAZR photoacoustic platform
MSK Applications
3D Power Doppler
3D power Doppler image of a swollen joint due to collagen-induced arthritis. Image courtesy of Dr. Mandl, University of Vienna, Austria.
Vascular Imaging
3D image illustrating the vascularity in the mouse paw in a model of collagen-induced arthritis. Image courtesy of Dr. Mandl, University of Vienna, Austria.
Photoacoustic Imaging
Multiplexed photoacoustic image of the mouse hindlimb after ICG injection (isolated in the popliteal lymph node).
Oxy-Hemo Mode
3D rendered image of oxygen saturation in the mouse ear, imaged with photoacoustics in Oxy-Hemo Mode.
Use Vevo Ultrasound to Image:
• Collagen induced arthritis (CIA)
• TNFa overexpressing animals
• Musculoskeletal (MSK) disease
Gallery
Imaging of lymphatics in the mouse.
High-resolution ultrasound (greyscale) and photoacoustic (red, blue and green) image of the mouse hindlimb showing Evan's Blue (blue) and ICG (green) dye in the lymphatic vessels and the popliteal lymph node.
Mouse hindlimb showing blood and ICG
3D rendered high-resolution ultrasound (greyscale) and spectrally unmixed photoacoustic (red, blue and green) image of the mouse hindlbimb. The green color indicates ICG dye in the popliteal lymph node after a hindpaw injection, the red color indicated oxygenated hemoglobin and the blue color indicates deoxygenated hemoglobin.
Mouse hindlimb with ICG in lymph node
3D rendered high-resolution ultrasound (greyscale) and spectrally unmixed photoacoustic (green) image of the mouse hindlbimb. The green color indicates ICG dye in the popliteal lymph node after a hindpaw injection.
Mouse ear vasculature
3D rendering of a photoacoustic parametric map of oxygen saturation in the mouse ear. Red pixels indicate higher sO2 values.
Arthritic Mouse Paw
Rendered 3D power Doppler image of an arthritic mouse paw with bone erosion.
Femoral Artery Bifurcation
Bifurcation of the femoral artery in the mouse seen using color Doppler.
Publications
TOP PAPER
Modulation of vascular response after injury in the rat Achilles tendon alters healing capacity
Journal of Orthopaedic Research
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TOP PAPER
Clinically-applicable perfluorocarbon-loaded nanoparticles for in vivo photoacoustic,19f magnetic resonance and fluorescent imaging
Nanotheranostics
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TOP PAPER
Tetrazine-Derived Near-Infrared Dye as a Facile Reagent for Developing Targeted Photoacoustic Imaging Agents
Molecular Pharmaceutics
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TOP PAPER
Accuracy of Ultrasound-Guided versus Landmark-Guided Intra-articular Injection for Rat Knee Joints
Ultrasound in Medicine & Biology
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TOP PAPER
Ultrasound as a New Imaging Tool to Assess Pathological Change of Joints in Preclinical Mouse Models of Osteoarthritis
Journal of Orthopaedics and Physiotherapy
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Dental Pulp Mesenchymal Stem Cells Attenuate Limb Ischemia via Promoting Capillary Proliferation and Collateral Development in a Preclinical Model
Stem Cells International
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Regional variation of corneal stromal deformation measured by high-frequency ultrasound elastography
Experimental Biology and Medicine
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Nerve Growth Factor-Targeted Molecular Theranostics Based on Molybdenum Disulfide Nanosheet-Coated Gold Nanorods (MoS2-AuNR) for Osteoarthritis Pain
ACS Nano
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