Seeing More Matters – in Mouse Rheumatoid Arthritis

How much inflammation is in the arthritic joints? Assess the musculoskeletal system with Vevo technology!

Rapid, completely non-invasive visualization of the arthritic joint using Ultra High Frequency Ultrasound and photoacoustics. See changes in tissue and vascular structure in 2D and 3D with resolution down to 30 microns. Tissue oxygenation, capillary function, tissue inflammation, bone erosion and more can be assessed longitudinally without interfering with your experiment.

•    Detect early onset of arthritis in drug-induced or spontaneous mouse models
•    Assess levels of inflammation
•    3D reconstruction of joints
•    Perform image guided injections (e.g. into the knee)
•    Detect hemoglobin and oxygenation levels with the Vevo LAZR photoacoustic platform
 

3D power Doppler image of a swollen joint due to collagen-induced arthritis. Image courtesy of Dr. Mandl, University of Vienna, Austria.

3D image illustrating the vascularity in the mouse paw in a model of collagen-induced arthritis. Image courtesy of Dr. Mandl, University of Vienna, Austria.

Multiplexed photoacoustic image of the mouse hindlimb after ICG injection (isolated in the popliteal lymph node).

3D rendered image of oxygen saturation in the mouse ear, imaged with photoacoustics in Oxy-Hemo Mode. 

Use Vevo Ultrasound to Image:

•    Collagen induced arthritis (CIA)
•    TNFa overexpressing animals
•    Musculoskeletal (MSK) disease