Pancreatic CancerRobust tool for studying orthotopic tumors
A Comprehensive Solution for Pancreatic Cancer Researchers
VisualSonics offers your complete imaging solution for orthotopic pancreatic cancer models, from model generation with image-guided injection to characterization of the tumor micro-environment. Vevo technology enables you to get a complete understanding of the anatomy and physiology in your specific tumor models and monitor response to treatment longitudinally.
Non-invasively perform everything from monitoring tumor size, vascularity, perfusion kinetics or oxygen saturation to quantification of targeted agents, all in one system!
Anatomical location of the healthy mouse pancreas with ultrasound. The head of the pancreas is seen on the left and the tail of the pancreas can be visualized on the right.
Your multimodal solution for robust evaluation of pancreatic tumor models:
• Non-invasively inject and generate orthotopic models with precision
• Quickly and accurately measure tumor size longitudinally
• Characterize tumor micro and macro vasculature in response to treatment
• Assess intratumoral hypoxia
• Perform targeted measurements of nanomedicines or theranostic agents
Image-guided Needle Injection
Example of image guided injection into the tail of the mouse pancreas. This technique can be used to deliver cancer cells to develop a model, as a non-invasive alternative to surgery.
Left: Small pancreatic tumor in a mouse model with approximate sizing in purple.
Right: 3D Color Doppler image of a pancreatic tumor (yellow) and the kidney (blue) with volumetrics performed.
Left: Murine pancreatic tumor shown in 3D with color Doppler highlighting major vasculature going away from the transducer (blue) and towards the transducer (red).
Right: B-Mode image of a murine pancreatic tumor (circled in yellow) on left with co-registered photoacoustic Oxy-Hemo Mode on right. Red depicts oxygenated hemoglobin and blue depicts deoxygenated hemoglobin.
Downloaded or access resources related to A Comprehensive Solution for Pancreatic Cancer Researchers
Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110
Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1
Biomimetic nanoparticles delivered hedgehog pathway inhibitor to modify tumour microenvironment and improved chemotherapy for pancreatic carcinoma
Thank you for your patience. Your search results are loading.