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Fibroblast Growth Factor 7 Limits Fibroblast-Driven Matrix Remodeling in Abdominal Aortic Aneurysm
Abdominal aortic aneurysm (AAA) is a chronic vascular disorder characterized by progressive aortic dilation and extracellular matrix remodeling, for which effective pharmacological therapies remain limited. Fibroblast growth factor 7 (FGF7), a paracrine …
Publication
Shear Wave Elasticity Imaging for Monitoring Risk of Skin Breakdown Following Subcutaneous Implantation
Subcutaneous implants are widely used in craniofacial reconstruction to restore structural integrity and aesthetics; however, complications such as skin breakdown and implant exposure remain common and can significantly impact patient outcomes. These …
Publication
Targeted LVA Guided by Ultra-High Frequency Ultrasound and ICG Lymphography: A Pilot Study
Targeted LVA Guided by Ultra-High Frequency Ultrasound and ICG Lymphography: A Pilot Study …
Publication
Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution
Tumour progression towards dedifferentiated cell clusters plays a critical role in intratumour heterogeneity and therapy resistance. While tumour microenvironmental stress has been implicated, the underlying mechanisms remain poorly defined. Using mouse …
Publication
Induction of subtle blood-brain barrier dysfunction using preclinical diagnostic ultrasound combined with microbubbles
Background: The blood–brain barrier (BBB) plays a critical role in maintaining brain homeostasis by tightly regulating molecular transport. However, its integrity is often compromised with aging and in neurodegenerative diseases, contributing to disease …
Publication
VSIG4 suppresses antitumor T cell immunity via the SLC3A2-dependent metabolic-ionic checkpoint
BackgroundImmune checkpoint blockade therapy aims to restore T-cell function within the tumor microenvironment (TME), eliciting durable antitumor responses. However, clinical response rates to PD-1/PD-L1 inhibitors remain limited, particularly in …
Publication
PM2.5 promotes the phenotypic transition of vascular smooth muscle cells in atherosclerosis by activating pro-ferroptotic signaling via DRP1/PINK1/Parkin-dependent mitophagy
PM2.5 promotes the phenotypic transition of vascular smooth muscle cells in atherosclerosis by activating pro-ferroptotic signaling via DRP1/PINK1/Parkin-dependent …
Publication
High-contrast ultrafast ultrasound power doppler imaging using subarray adaptive temporal autocorrelation with phase compensation
Compared to the conventional zero-lag autocorrelation (R(0)) estimation which directly accumulates the power of Doppler ensembles for ultrafast ultrasound power Doppler (PD) imaging, first-lag autocorrelation (R(1)) enhances the noise suppression in PD …
Publication
Hypoxia-adaptive albumin nanosystem modulates lactate metabolism to in situ activate postoperative immunotherapy
Postoperative tumor microenvironment (TME) exemplified by high-intensity focused ultrasound (HIFU), is characterized by severe hypoxia and lactate accumulation, which greatly impairs the body’s antitumor immune responses, resulting in poor overall …
Publication
Exacerbated expansive vascular remodeling due to disturbed flow in male mice overexpressing protein disulfide isomerase‐ <scp>A1</scp>
Vascular expansive remodeling is involved in atherosclerosis/restenosis; however, its mechanisms need further investigation. Protein‐disulfide isomerase (PDIA1), a redox chaperone from the endoplasmic reticulum and cell surface, supports vascular smooth …