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Dual-modal photoacoustic and ultrasound imaging for early diagnosis of ovarian torsion and evaluation of long-term tissue hypoxia
Ovarian torsion (OT), a critical gynecological emergency caused by ovarian twisting and vascular compromise, risks necrosis without prompt intervention. This study evaluated dual-modal photoacoustic/ultrasound imaging for early detection and chronic …
Publication
Melatonin attenuates atherosclerotic plaque vulnerability through SIRT6-dependent regulation of vascular smooth muscle cells senescence
Rupture of vulnerable atherosclerotic plaques is a major cause of acute cardiovascular events. Vascular smooth muscle cell (VSMC) senescence promotes plaque vulnerability by impairing fibrous cap integrity. Although melatonin exhibits atheroprotective …
Publication
Magnetically-Induced Suppression of Oxidative Stress Prevents Venous Thrombosis
Venous thrombosis remains a major clinical challenge, with current therapeutic options limited by bleeding risks and procedural invasiveness. Here, it is demonstrated that static magnetic fields (SMFs) provide a non-invasive and effective strategy for …
Publication
Targeting the Notch1-YY1-ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T-Cell-Driven Cancer Cell Pyroptosis
Immunotherapy has shown a modest clinical benefit in advanced hepatocellular carcinoma (HCC), probably due to tumor immunosuppressive functions. Although Notch1 signaling has been implicated in tumor immune escape, its underlying mechanism is unclear. …
Publication
Extracellular vesicles from Yiguanjian-primed bone-marrow mesenchymal stem cells ameliorate chronic liver fibrosis via miR-7045-5p
Background: Liver fibrosis is a crucial pathological stage in the progression of chronic liver diseases. Yiguanjian (YGJ), a Chinese herbal formula, exhibits anti-inflammatory, anti-fibrotic, and hepatoprotective effects. Extracellular vesicles from …
Publication
Photoacoustic Imaging of Muscle Tissue Oxygenation as a Noninvasive Biomarker in Mouse Models of Sickle Cell Disease
Purpose: To develop and validate photoacoustic imaging (PAI) as a method to assess hemoglobin counts and muscle tissue oxygen saturation in a mouse model of Sickle Cell Disease (SCD. Procedures: In vivo PAI was performed on mice with a SCD phenotype and …
Publication
From 2D to 3D: Automated ultrasound segmentation and cross-sectional validation in murine tumor models
Background and Objective Ultrasound (US) is a widely used method for non-invasive tumor monitoring. Semantic segmentation of tumors in US imagery is a necessary step to reconstruct 3D geometry of a region of interest (ROI). Still, the segmentation task …
Publication
A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1
Biosynthesis of all androgens and estrogens from cholesterol requires CYP11A1 and CYP17A1. There is no known pathway in humans or other vertebrates that circumvents CYP17A1 for androgen or estrogen biosynthesis in physiology or disease. However, CYP17A1 …
Publication
Pulmonary ultrasound provides a more accurate assessment of pulmonary congestion than wet/dry lung weight in rats
Pulmonary congestion is a common complication in critically ill patients, but its quantification remains challenging. The wet-to-dry (W/D) lung weight ratio, widely used in experimental models, is a terminal and semi-quantitative method. Lung …
Publication
Refining the Guinea Pig (Cavia porcellus) Cryo-Injury Model for Cardiac Regeneration and Functional Characterization
Guinea pigs have been a standard model in cardiovascular pharmacology and physiology research, but the advent of transgenic models has largely replaced them with mouse and rat models. However, guinea pigs remain important models in cardiac …