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Seeing Hypoxia: High-resolution, in vivo oximetry

While methods exist for measuring blood oxygenation, they can be invasive, low temopral and/or spatial resolution, superficial or expensive.  Because oxy- and deoxyhemoglobin absorb light differently at different wavelengths, photoacoustic imaging can be used to generate a high resolution parametric map of the oxygen saturation of blood completely non-invasively.  This allows for the real-time monitoring of functional processes with the added advantage of haivng this oximetry data fused with high resolution anatomical images.

Oxy-Hemo mode can be used for:

Cancer imaging - Oxygen saturation in a mouse subcutaneous tumor
Subcutaneous tumor showing spatial distribution of oxy and deoxyhemoglobin for hypoxia assessment

Oxygen saturation in E14 mouse embryo and placenta
E14 embryo (right) and associated placenta (left) showing oxygenation distribution