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HSP47 is a potential dual cell target and prognostic factor in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a dismal 5-year survival rate at 12%. The fibrotic PDAC desmoplasia is a major contributor to chemoresistance and metastasis that drive this poor prognosis. Cancer-associated fibroblasts …
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Dual inhibition of PRMT1 and SUV39H1 suppresses breast cancer progression and enhances immunotherapy response
Protein arginine methyltransferase 1 (PRMT1) dysregulation is frequently observed in various human cancers, including breast cancer. However, the antitumor efficacy of PRMT1 inhibitors remains limited in the treatment of breast cancer. Here, we propose a …
Publication
Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target
Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic …
Publication
Ultrasound-based estimation of periodontal probing depth using category-specific supracrestal tissue attachment calibration
Ultrasound-based estimation of periodontal probing depth using category-specific supracrestal tissue attachment calibration …
Publication
Refining a preclinical model of viral myocarditis in accordance with biotech standards
Background: Viral myocarditis is a clinically relevant inflammatory heart disease that can progress to dilated cardiomyopathy and heart failure. However, preclinical models often suffer from limited translational relevance and high animal burden. Methods: …
Publication
Comprehensive Landscape of Post-Translational Modification Alterations in Nephrolithiasis Revealing Activation of Multiple Cell Death Pathways
Nephrolithiasis is a common urinary disorder characterized by high prevalence and recurrence, but the molecular mechanisms underlying calcium oxalate (CaOx)-crystal-induced renal injury remain incompletely understood. We applied integrated proteomic, …
Publication
Realistic Ultrasound Simulations of Healthy and Osteoarthritic Cartilage
Osteoarthritis (OA) causes irreversible cartilage damage, highlighting the need for early and sensitive assessment. Current imaging modalities are limited in detecting early-stage changes. Ultrasound (US) provides a non-invasive and accessible …
Publication
Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic cancer
Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic …
Publication
Altered bone marrow niche forms central innate immune memory driving cardiac dysfunction
We previously showed that heart failure induces innate immune memory in hematopoietic stem and progenitor cells, which contributes to recurrence of heart failure and impaired stress responses in multiple organs. While the bone marrow microenvironment …
Publication
Green surfactants reveal mechanistic principles governing polymeric microbubble formation and function
Greener non-ionic surfactants replace Triton X-100 in polymeric microbubble synthesis, revealing how hydrophobic tail structure, PEG length, and HLB engineer microbubble yield, morphology, shell composition, drug loading, and acoustic …