Neurobiology
Neuroimaging Techniques for Seeing the Mouse Brain in vivo and in Real-time
Visualize functional processes for your small animal neuroscience research including stroke, cancer and in vivo delivery of drugs, stem cells, or other agents.
Compared to other preclinical neuroimaging techniques, Vevo imaging systems are non-invasive, non-ionizing, and offer a more cost effective solution.
Ultra-high frequency ultrasound and photoacoustic imaging is capable of assessing many neurologically relevant parameters in 2D and 3D such as:
- Blood flow
- Perfusion
- Oxygen saturation
- Total Hemoglobin
- Contrast agents (ultrasound microbubbles, NIR dyes, nanoparticles)
In addition, the Vevo BRAIN stereotactic frame and neuroanatomical atlas facilitates mouse brain imaging for increased ease-of-use and reproducibility.
Imaging the Brain
Vasculature in the Brain during Ischemic Stroke
Vasculature in the mouse brain, visualized with color Doppler during transient carotid artery occlusion.
Gallery
Juvenile rat cerebral vasculature
Lesion in Embryo Spine - Spina Bifida Rat Model
Spina bifida is a neural tube defect that results in incomplete closing of the spinal cord. Spina bifida is associated with abnormalities in the cerebellum and cisterna magna during fetal development. This image acquired using the Vevo 3100.
Embryo Cerebellum - Spina Bifida Rat Model
Spina bifida is a neural tube defect that results in incomplete closing of the spinal cord. Spina bifida is associated with abnormalities in the cerebellum and cisterna magna during fetal development. This image acquired using the Vevo 3100.
Screenshot of mouse brain atlas
Screenshot of the Vevo LAB software displaying several different views of the CD-1 mouse brain atlas which comes with the Vevo BRAIN stereotactic frame.
Neuroanatomy of the mouse brain
3D rendered surface view of the mouse brain segmented by anatomical region based on ex vivo high frequency ultrasound images.
Ischemia/hypoxia stroke model
Plot of oxygen saturation (sO2) over time in the left (pink) and right (orange) cortical and subcortical hemisphere ROIs while restoring breathed oxygen to 100% from 7.5% post ischemia/hypoxia for stroke induction. Ultrasound (top) and photoacoustic (bottom) coronal images in the right panel show a frame of mouse brain post ischemia/hypoxia.
Publications
Cerebral organoids display dynamic clonal growth and tunable tissue replenishment
Nature Cell Biology
, Ex vivo method for rapid quantification of post traumatic brain injury lesion volumes using ultrasound
Journal of Neuroscience Methods
, Reduced fetal cerebral blood flow predicts perinatal mortality in a mouse model of prenatal alcohol and cannabinoid exposure
BMC Pregnancy and Childbirth
, Ultra-photostable small-molecule dyes facilitate near-infrared biophotonics
Nature Communications
, Targeted opening of the blood-brain barrier using VCAM-1 functionalised microbubbles and “whole brain” ultrasound
Theranostics
, Impaired memory in Sprague-Dawley rats exposed to complex groundwater mixtures of contaminants is associated with reduced cranial blood flow and hippocampal neurotoxicity
NeuroToxicology
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