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Submicron-sized ultrasound contrast agents as therapeutic peptide delivery vehicles in type 1 diabetes
Type 1 diabetes (T1D) is an autoimmune disease where autoreactive T cells infiltrate pancreatic islets, resulting in beta-cell destruction. Antigen-specific immunotherapy with tolerogenic peptides to induce peripheral tolerance has shown promise in …
Publication
Lithocholic acid-activated VDR in macrophages promotes HCC recurrence post-ablation via SOCS3-mediated suppression of CXCL16
Lithocholic acid-activated VDR in macrophages promotes HCC recurrence post-ablation via SOCS3-mediated suppression of CXCL16 …
Publication
G6PD inhibition prevents abdominal aortic aneurysm formation in mice induced by Ang II plus high salt
G6PD inhibition prevents abdominal aortic aneurysm formation in mice induced by Ang II plus high salt …
Publication
Endothelial cell-specific knockout of ATG5 ameliorates inflammation and renal fibrosis by regulating pyroptosis
Objectives: ATG5, a key regulator of autophagy-associated inflammation, is markedly upregulated under inflammatory conditions. In this study, we observed significantly elevated ATG5 expression in the kidneys of patients with renal fibrosis and in mouse …
Publication
Aortic asprosin overexpression does not ameliorate disease pathophysiology in a murine model of Marfan syndrome
Marfan syndrome (MFS) is a connective tissue disorder caused by FBN1 mutations, characterised by aortic aneurysms leading to life-threatening dissections. Asprosin is the C-terminal propeptide of fibrillin-1 that was shown to function as a glucogenic …
Publication
Time-Series Analysis of Pregnancy and Childbirth Effects on Pelvic Floor Muscle Electrophysiology and Morphology in Rats
Introduction and Hypothesis: This study examined the differential effects of pregnancy and parturition on electrophysiological and histomorphometric properties in rat pelvic floor muscle (PFM) groups to provide a theoretical basis for targeted electrical …