Vevo CQ Software allows advanced quantification of perfusion kinetics with consistent and reliable data
Vevo CQ is a powerful addition to nonlinear contrast imaging functionality on the Vevo imaging platforms. This software allows you to study contrast uptake kinetics as well as late phase targeted enhancement. It provides advanced curve fitting algorithms for quantitative assessment of perfusion parameters as well as color-coded parametric images useful for qualitative assessment of spatial distribution. Vevo CQ is a post-processing tool which can be used on numerous tissues, organs and tumor models, including subcutaneous tumors, abdominal organs and hind limb muscles.
Workflow includes:
1. User-Defined Regions of Interest Selection
The ability to define multiple areas of interest allows selection and detection of anatomical regions with differing perfusion kinetics (i.e. tumor and surrounding normal tissue or multiple areas within a tumor).
Example of four user defined regions of interest in a subcutaneous tumor
2. Curve Fitting Capabilities
Three options are available such that data is plotted and generated for both perfusion and targeted molecular imaging studies.
Bolus perfusion curves for each region of interest in a subcutaneous tumor
3. Data Quantification
A multitude of quantification tools are available to generate data related to perfusion kinetics as well as molecular imaging.
Output Parameters for Bolus Perfusions
| PE | Peak Enhancement | [a.u.] |
| AUC | Area Under the Curve | [a.u.] |
| RT | Rise Time | [s] |
| TTP | Time to Peak | [s] |
| WiR | Wash-in Rate (maximum slope) | [a.u.] |
| PI | Perfusion Index (AUC / RT) | [a.u.] |
Output Parameters for Destruction-Replenishment Reperfusion
| rBV | relative Blood Volume (A) | [a.u.] |
| mTT | mean Transit Time | [s] |
| rBF | relative Blood Flow (rBV / mTT) | [a.u.] |
4. Parametric imaging
Allows a visualize display of the intensity of perfusion kinetics and molecular signal.
Parametric image from bolus perfusion model in the liver, showing peak enhancement
Images and videos can be exported in a variety of formats such as TIFF, Bitmap and WMV.
* Copyright © Bracco Suisse SA - 2010