In Vivo Imaging for Preclinical Research

Seeing More Matters to Researchers

What is 'in vivo' imaging?

Studies in which research is conducted on whole, living organisms, be it animals, humans or plants.

What are the benefits to in vivo Imaging?

  • Provides unique insights into complex biological processes
  • Often replaces more rudimentary and less accurate techniques, such as measuring tumor volume with calipers
    • Advanced technologies more accurately determine volume and location
  • Essential bridge between in vitro data and clinical translation
  • Facilitates translational drug development

Key Imaging Technology & Applications

Imaging technologies such as our Vevo F2 (ultra high-frequency ultrasound) and the Vevo LAZR-X20 (photoacoustic imaging) allow researchers to acquire high-resolution images and robust anatomical, functional and molecular data, helping advance biomedical research.

Our non-invasive system supports various animal disease models across numerous applications.

OncologyCardiologyNeurobiology
  • Tumor hypoxia assessment
  • Tumor angiogenesis assessment
  • Biodistribution of molecular probes
  • Cardiac hemodynamics including ischemia and oxygen saturation
  • Vascular malformations
  • Cell tracking in the myocardium
  • Cerebral hemodynamics
  • Detection of blood-brain-barrier (BBB) disruption
  • Label-free detection and assessment of stroke
DevelopmentMolecular
  • Developmental toxicity and drug trials
  • Fetal programming
  • Pregnancy research and pregnancy complications
  • Characterization of nanoparticles and dyes
  • Sentinel lymph node mapping
  • Whole-body biodistribution and pharmacokinetics

How do Vevo Systems Implement the 3Rs?

ReplacementReductionRefinement
With ultrasound, you can use the same animal throughout the study; resulting in fewer animals being used across your studies.The ability to monitor the same animal as the control throughout your studies reduces the amount of animals needed to acquire results; increasing statistical power.Our Vevo systems use ultrasound and anaesthesia to image animals, resulting in minimal harm and distress to the research animal.

Non-invasive, in vivo imaging supports longitudinally studies in order to reduce overall animal usage.

Advancements in imaging technology and software are helping researchers around the world expand their research further than ever before!

Let's Talk 3Rs

Animal Welfare and Multi-modal Imaging

Want to learn more about the 3Rs? Watch our collection of workshop videos talking all about how ultrasound imaging can help advance your research non-invasively with experts in the industry.

Learn more