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Characterization of fluxapyroxad-induced cardiotoxicity in zebrafish
Characterization of fluxapyroxad-induced cardiotoxicity in zebrafish …
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Comparison of cardiac regeneration capacity between zebrafish and medaka reveals a regenerative response in both teleost species
Danio rerio (zebrafish) can regenerate their heart upon loss of over 20% of the total myocardium. A second teleost species, Oryzias latipes (medaka), however, has been described to lack this capacity and respond to a lesion forming a permanent fibrotic …
Publication
Contrast-enhanced ultrasound and photoacoustic imaging to assess early and late renal ischemia-reperfusion injuries in male mice
Tissue perfusion and oxygenation, key factors of renal ischemia-reperfusion injury (RIR), can be assessed using contrast-enhanced ultrasound (CEUS) and photoacoustic (PA) imaging. We hypothesized that early changes in renal perfusion and oxygenation …
Publication
Aortic Segments-Depending Hypertensive Remodeling Is Driven by Mitochondrial Fusion Dysfunction
OPA1 haploinsufficiency exacerbates severe hypertension-induced aortic remodeling in a segment-specific manner, revealing differential vulnerability between the suprarenal abdominal aorta (SRAA) and the descending thoracic aorta (DTA). In the SRAA, …
Publication
Protocol for inducing deep vein thrombosis in C57BL/6J mice using the inferior vena cava stenosis model
Here, we present a protocol for inducing deep vein thrombosis (DVT) in C57BL/6J mice using the inferior vena cava (IVC) stenosis model. We describe steps for surgical preparation, IVC ligation, and non-invasive detection and confirmation of thrombus …
Publication
Theaflavin alleviates thoracic aortic dissection by disrupting the interaction between microtubule affinity-regulating kinase 4 and NLRP3 to inhibit inflammasome assembly
Theaflavin alleviates thoracic aortic dissection by disrupting the interaction between microtubule affinity-regulating kinase 4 and NLRP3 to inhibit inflammasome …
Publication
Molecular Mechanisms of Indoor Environmental Pollution tt-DDE-Induced Blood Pressure Elevation and the Protective Role of Human-Specific Gene CHRFAM7A
Molecular Mechanisms of Indoor Environmental Pollution tt-DDE-Induced Blood Pressure Elevation and the Protective Role of Human-Specific Gene …
Publication
Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1
Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1 …
Publication
Luteolin decreases sFlt-1 and mean arterial pressure in the RUPP animal model of placental ischemia
Objectives: Preeclampsia (PE) is a complication of pregnancy and a leading cause of maternal and fetal morbidity and mortality. Despite being prevalent and highly morbid, there are no approved treatments to relieve PE signs and symptoms. Many studies have …
Publication
Machine-intelligent multimodal algebot for intracavitary chemotherapy
Intracavitary drug instillation is a crucial therapeutic strategy for treating bladder cancer. However, current methods are limited in efficacy due to insufficient tumour targeting and drug penetration across tissue barriers in pathophysiological …