Parental obesity exacerbates cognitive dysfunction and cardiac vulnerability in offspring of an Alzheimer disease model

Jussara M., do Carmo, John E., Hall, Emily, Ladnier, Xuemei, Dai, Zhen, Wang, Alan J., Mouton, Ana C. M., Omoto, Luciana, Jorge, Alexandre A., da Silva

American Journal of Physiology-Heart and Circulatory Physiology |

Parental obesity is associated with worsened cognitive performance and male-specific impairments in cardiac metabolism and function in AD-susceptible offspring, highlighting developmental programming as a modifier of heart-brain vulnerability.

https://journals.physiology.org/doi/10.1152/ajpheart.00047.2026