Biomarker / Molecular ImagingVisualize deep within the anatomy of small animal subjects in 2D or 3D
Characterize, Visualize, Analyze Biomarkers Deep within the Anatomy
Quantification of biomarkers with contrast agents for ultrasound and photoacoustic imaging modes.
Biomarker research contributes significantly to breakthroughs in the understanding of disease progression as well as the validation of therapeutic treatments. Using ultrasound and photoacoustic contrast agents with the Vevo systems, biomarkers can thus be visualized deep within the anatomy of the animal in 2D or 3D with resolutions down to 30 µm completely non-invasively.
Published molecular imaging applications using the Vevo systems include biomarker quantification, monitoring drug delivery, cell tracking, diagnostics such as detection of metastatic cells, development and characterization of novel theranosic contrast agents and others.
Visualize and Quantify
Targeted Molecular Imaging
Track stem cells, immune cells or bacterial infection in vivo.
Use melanin for genetically-encoded optical contrast to detect tumors or expression of biomarkers.
Track pharmacokinetics and drug delivery in whole-body or organ-specific microdistribution.
Identify biomarkers in vivo with high resolution, and visualize multiple targets simultaneously.
In the drug development space, the multi-modal nature of the Vevo systems make them ideal for assessing response to therapy including morphology, tumor volume, angiogenesis, vascularity, perfusion and hypoxia as well as for assessing cardiotoxicity.
Mouse Kidney Perfusion with Non-Targerted Microbubbles Imaged in Non-Linear Contrast Mode.
Tumor Perfusion with Non-Targerted Microbubbles, Imaged with Non-Linear Contrast and Displayed as MIP.
3D rendering of a photoacoustic image (overlaid onto B-Mode) of the mouse hind limb after Indocyanine Green (ICG) injection that migrated into the inguinal lymph node. Hind Limb vasculature can be seen in red and purple.
Molecular imaging can be performed on the Vevo imaging system using two categories of contrast agents:
- Non-toxic, micron-sized agents which stay within the vasculature
- Sensitivity down to the capillary level
- Contrast agents can be targeted or untargeted
- Truly translational - used in the clinic
- Typically sub-100nm sized agents which can extravasate for tissue labeling
- Can be customized for a wide variety of targets and applications
- Can be multi-modal for PET, MR, Optical or other imaging compatability
Performances of a Pristine Graphene-Microbubble Hybrid Construct as Dual Imaging Contrast Agent and Assessment of Its Biodistribution by Photoacoustic Imaging
Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors
Intraoperative Resection Guidance with Photoacoustic and Fluorescence Molecular Imaging Using an Anti-B7-H3 Antibody-Indocyanine Green Dual Contrast Agent
Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer
Multispectral Photoacoustic Imaging of Tumor Protease Activity with a Gold Nanocage-Based Activatable Probe
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