Here, we present a protocol for inducing deep vein thrombosis (DVT) in C57BL/6J mice using the inferior vena cava (IVC) stenosis model. We describe steps for surgical preparation, IVC ligation, and non-invasive detection and confirmation of thrombus …

Theaflavin alleviates thoracic aortic dissection by disrupting the interaction between microtubule affinity-regulating kinase 4 and NLRP3 to inhibit inflammasome …

Molecular Mechanisms of Indoor Environmental Pollution tt-DDE-Induced Blood Pressure Elevation and the Protective Role of Human-Specific Gene …

Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1 …

Objectives: Preeclampsia (PE) is a complication of pregnancy and a leading cause of maternal and fetal morbidity and mortality. Despite being prevalent and highly morbid, there are no approved treatments to relieve PE signs and symptoms. Many studies have …

Intracavitary drug instillation is a crucial therapeutic strategy for treating bladder cancer. However, current methods are limited in efficacy due to insufficient tumour targeting and drug penetration across tissue barriers in pathophysiological …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a dismal 5-year survival rate at 12%. The fibrotic PDAC desmoplasia is a major contributor to chemoresistance and metastasis that drive this poor prognosis. Cancer-associated fibroblasts …

Protein arginine methyltransferase 1 (PRMT1) dysregulation is frequently observed in various human cancers, including breast cancer. However, the antitumor efficacy of PRMT1 inhibitors remains limited in the treatment of breast cancer. Here, we propose a …