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Mechanical loading-induced bone formation is associated with increased blood velocity and vascular canal bone porosity, with localized vascular adaptation
Bone is a highly vascularized tissue, which is useful for the metabolically demanding process of remodeling. Blood vessels are important in the fluid movement that occurs during bone mechanoadaptation. We hypothesized that in-vivo mouse tibial loading, …
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Correlation of ultrasound attenuation with proton density fat fraction across multiple organs in healthy volunteers
Background: Local determination of the attenuation in biological tissues has been the focus of extensive research over the past decades. Its characterization is of major interest for both noninvasive thermal therapies and diagnostic applications. Numerous …
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Intrathecal Delivery of Macromolecules to the Spinal Cord Enabled by Laser-Activated Perfluorocarbon Nanodroplets
Intrathecal Delivery of Macromolecules to the Spinal Cord Enabled by Laser-Activated Perfluorocarbon Nanodroplets …
Publication
BET-induced metabolic reprogramming fuels inflammation at the vascular-fat interface in mice and patients with cardiometabolic disease
Epigenetic reading of histone marks by BET proteins is emerging as a pivotal mechanism governing gene transcription and may be implicated in cardiometabolic disease (CMD). Using vessels from mice and patients with CMD, we show that pharmacological …
Publication
Cerebral arteries in mice with sickle cell disease are exposed to larger areas of low wall shear stress
Sickle cell anemia (SCA) is the most severe form of sickle cell disease and causes increased stroke risk, even in children. Hemodynamic mechanisms underlying cerebral vasculopathy remain unclear. To test the hypothesis that SCA causes disturbed flow and …
Publication
Bio-polymer based dynamically crosslinked hydrogel enabling photoacoustic monitoring of diabetic wound healing
In the present study, a renewable resource-based, dynamically cross-linked hydrogel was developed using a combination of polyvinyl alcohol (PVA), lignin (LIG), and quercetin (QUE). LIG was extracted from peanut shells and served as a renewable …
Publication
Exercise attenuates perivascular adipose tissue sympathetic innervation and regulates arterial stiffness in obese rats
Background/objectives: This study was designed to investigate the involvement of sympathetic innervation within perivascular adipose tissue (PVAT) during exercise regulating arterial stiffness in obese rats, and the potential neuro-vascular mechanism. …
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Quad-Channel In Vivo Photoacoustic Multiplexing Using Tunable Gold Nanorods
Photoacoustic (PA) imaging combines the molecular specificity of optical absorption with the resolution and depth of ultrasound, enabling noninvasive molecular imaging in vivo. However, robust and accurate PA multiplexing is hindered by the broad spectra …
Publication
A Bioorthogonal and Programmable Bacterial Delivery System for Spatiotemporally Targeted Therapy of Solid Tumors
Rapid advances in synthetic biology are driving the development of microbes as therapeutic agents. While the immunosuppressive tumor microenvironment creates a favorable niche for the systematic delivery of bacteria and therapeutic payloads, these can be …
Publication
Rejuvenation of corticospinal neurons enhances rehabilitation-associated corticospinal tract axon sprouting and functional recovery post photothrombotic ischemic stroke in mice
Rejuvenation of corticospinal neurons enhances rehabilitation-associated corticospinal tract axon sprouting and functional recovery post photothrombotic ischemic stroke in …