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Far-infrared irradiation attenuates vessel contraction by activating SERCA2 through disruption of SERCA2 and PLN interaction
Vascular smooth muscle cells (VSMCs) plays an important role in maintaining vascular function by responding to various vasoactive stimuli within blood vessels. Far-infrared (FIR) rays has been shown to possess a variety of physiological effects including …
Publication
Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency
Pulmonary fibrosis (PF) is a major cause of morbidity and mortality. Although increased oxidative stress and altered metabolism are implicated in PF pathobiology, our knowledge regarding the contribution of the glucose metabolism to the synthesis of …
Publication
Sub-millimeter quantification of alveolar bone loss using automated 40 MHz high-frequency ultrasound: A proof-of-concept ex vivo validation study
This proof-of-concept study evaluated the performance of high-frequency ultrasound (HFUS, 40 MHz) for monitoring changes in alveolar bone loss and determining its detection capability and measurement precision. The study aimed to quantify system error, …
Publication
Hypoxia shapes both therapeutic response and resistance in metastatic clear cell renal cell carcinoma
Vascular endothelial growth factor receptor-targeting tyrosine kinase inhibitors (VEGFR-TKIs) and anti-PD-1 (aPD-1) combinations are effective in multiple solid tumors, particularly in clear cell renal cell carcinoma (ccRCC), due to its characteristic …
Publication
The ADP-ribosyltransferases 3 (ART3) is a novel suppressor of pathological cardiac hypertrophy by ribosylating ITGA7
Pathological cardiac hypertrophy and heart failure remain mechanistically incompletely defined despite their clinical significance in cardiovascular disease. While ADP-ribosyltransferase cholera toxin-like (ARTC) enzymes modulate membrane protein function …
Publication
Spatiotemporal Deep Video-Phenomapping Decodes Microvascular Rarefaction in Renovascular Hypertension: A Multi-Modal Study Integrating Spatial Transcriptomics and Mitochondrial Pyroptosis
Spatiotemporal Deep Video-Phenomapping Decodes Microvascular Rarefaction in Renovascular Hypertension: A Multi-Modal Study Integrating Spatial Transcriptomics and Mitochondrial …
Publication
Fibronectin-induced overactivation of αVβ3-PI3K-PIP3-PDK1-ILK signaling drives aortic disease in Marfan syndrome
Thoracic aortic aneurysms and dissections (TAAD), a life-threatening complication of Marfan syndrome (MFS), lack curative therapies. Our previous studies revealed that versican accumulation drives MFS aortopathy through AKT-NO pathway overactivation, but …
Publication
Chromobox 3 assembles an epigenetic complex contributing to cystathionine γ-lyase–mediated protection against aortic aneurysm/dissection
Chromobox 3 assembles an epigenetic complex contributing to cystathionine γ-lyase–mediated protection against aortic aneurysm/dissection …
Publication
Lithocholic acid-activated VDR in macrophages promotes HCC recurrence post-ablation via SOCS3-mediated suppression of CXCL16
Lithocholic acid-activated VDR in macrophages promotes HCC recurrence post-ablation via SOCS3-mediated suppression of CXCL16 …
Publication
G6PD inhibition prevents abdominal aortic aneurysm formation in mice induced by Ang II plus high salt
G6PD inhibition prevents abdominal aortic aneurysm formation in mice induced by Ang II plus high salt …