Our Vevo LAZR-X photoacoustic imaging system enables targeted molecular imaging using exogenous contrast agents...
Oncology
Your Powerful Solution for Cancer Research
Cancer Imaging for Translational Research
Characterize tumor tissue in vivo, non-invasively, detect lesions early, monitor tumor development and assess response to therapy!
Vevo for Oncology: A Longitudinal Study Workflow
For more information on the longitudinal study workflow, download our Vevo for Oncology document.
With Vevo cancer imaging technology for translational research, you can perform image-guided injections to create orthotopic tumors, conduct high-throughput screenings for tumor growth and detect and monitor growth and response of tumors to therapy at multiple time points in preclinical disease models all in vivo. Vevo technology allows you to assess tumor size and volume accurately. Add imaging the tumor microenvironment for changes in angiogenesis, hypoxia, molecular markers, and drug delivery and you have a powerful multi-modal platform for oncology research.
With the Vevo Imaging Systems you can:
- Screen for very small lesions (resolution down to 30µm)
- Accurately quantify volume of orthotopic and subcutaneous tumors longitudinally
- Visualize and quantify angiogenesis, vasculature and perfusion
- Measure hypoxia
- Assess biomarker or drug distribution
- Develop models using ultrasound-guided injections
Oxygen saturation in a mouse subcutaneous tumor imaged using photoacoustics.
Bolus injection of non-targeted contrast agent to look at perfusion kinetics in a mouse bladder tumor.
(Left) B-Mode image-guided injection into a mouse tumor with injection and aspiration. This technique can be used for cancer model development.
Gain insights into various tumor models including:
- Orthotopic pancreatic tumors
- Breast tumors
- Prostate and ovarian cancer
- Bladder tumors
- Gliomas
- Patient-dervied xenografts
View literature published using the Vevo systems for these models and others.
See images and videos related to Cancer Imaging for Translational Research.
Displaying 1 - 5 of 611 results found
Top Paper
Morphological, functional, and molecular assessment of breast cancer bone metastases by experimental ultrasound techniques compared with magnetic resonance imaging and histological analysis
Henrik Heinen, Lisa Seyler, Vanessa Popp, Konstantin Hellwig, Aline Bozec, Michael Uder, Stephan Ellmann, Tobias Bäuerle
Bone
.2021
;Top Paper
Cysteine depletion induces pancreatic tumor ferroptosis in mice
Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer, Kathleen E. DelGiorno, Ho Joon Lee, Vinee Purohit, Irina R. Sagalovskiy, Alice Ma, Jonathan Kapilian, Christina E.M. Firl, Amanda R. Decker, Steve A. Sastra, Carmine F. Palermo, Leonardo R. Andrade, Peter Sajjakulnukit, Li Zhang, Zachary P. Tolstyka, Tal Hirschhorn, Candice Lamb, Tong Liu, Wei Gu, E. Scott Seeley, Everett Stone, George Georgiou, Uri Manor, Alina Iuga, Geoffrey M. Wahl, Brent R. Stockwell, Costas A. Lyssiotis, Kenneth P. Olive
Science
.2020
;Top Paper
Contrast-Enhanced Multispectral Photoacoustic Imaging for Irregular Hepatectomy Navigation: A Pilot Study
Yueming Zhang, Jing Lv, Pingguo Liu, Xingyang Zhao, Kang Chen, Qiaolin Li, Liming Nie, Chihua Fang
ACS Biomaterials Science & Engineering
.2020
;Top Paper
Tetrazine-Derived Near-Infrared Dye as a Facile Reagent for Developing Targeted Photoacoustic Imaging Agents
Samantha Slikboer, Zoya Naperstkow, Nancy Janzen, Amber Faraday, Yohannes Soenjaya, Johann Le Floc’h, Salma Al-Karmi, Rowan Swann, Kevin Wyszatko, Christine E. M. Demore, Stuart Foster, John F. Valliant
Molecular Pharmaceutics
.2020
;Top Paper
Noninvasive monitoring of liver metastasis development via combined multispectral photoacoustic imaging and fluorescence diffuse optical tomography
Jonathan Lavaud, Maxime Henry, Pascal Gayet, Arnold Fertin, Julien Vollaire, Yves Usson, Jean-Luc Coll, Véronique Josserand
International Journal of Biological Sciences
.2020
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Assessment of Murine Colorectal Cancer by UHF Ultrasound using 3D Reconstruction and Non-Linear Contrast Imaging
“Utilizing the Vevo2100 to assess orthotopic colorectal cancer in mice has proven instrumental to our data quality. Instead of using endpoint-only data for our studies, we are now able to collect high-resolution longitudinal data, making sure to capture responses to treatment that otherwise would have been missed. The true value lies in the fact that we can collect data that is giving us tumor VOLUMES rather than just tumor areas, enabling us to know more about the tumor morphology. And using non-linear contrast combined with microbubbles we are able to further investigate the vascularity of the colon as a whole as well as individual tumors. Knowing how those tumors recruit vessels to feed them and if our treatments can influence this vascular recruitment may be the key to finding worthwhile therapies.”
~ Jessical Freeling, MS, VT, LATG, Physiology Core Laboratory Manager,
The University of South Dakota