Background and Objective Characterizing the tumor microenvironment (TME) requires integrating multiple physiological features, including oxygenation, vascularity, and redox status. While EPR oxygen imaging (EPROI) provides spatial pO₂ maps, conventional …

Photoacoustic/ultrasound (PA/US) imaging can enable noninvasive periodontal diagnosis, but conventional probes are bulky and couple poorly, limiting access to posterior teeth. We developed a miniaturized dual-mode toothbrush-shaped transducer with a …

Preclinical multimodal imaging is widely applied in small animal models for longitudinal studies of human diseases. Beyond murine systems, cost-effective and ethically sustainable models such as the chicken embryo and its chorioallantoic membrane are …

Intra-operative application of ultra-high frequency ultrasound facilitates differentiation of bowel wall characteristics between ganglionic and aganglionic segments during transanal endorectal pull-through for Hirschsprung …

Bone is a highly vascularized tissue, which is useful for the metabolically demanding process of remodeling. Blood vessels are important in the fluid movement that occurs during bone mechanoadaptation. We hypothesized that in-vivo mouse tibial loading, …

Background: Local determination of the attenuation in biological tissues has been the focus of extensive research over the past decades. Its characterization is of major interest for both noninvasive thermal therapies and diagnostic applications. Numerous …

Intrathecal Delivery of Macromolecules to the Spinal Cord Enabled by Laser-Activated Perfluorocarbon Nanodroplets …

Epigenetic reading of histone marks by BET proteins is emerging as a pivotal mechanism governing gene transcription and may be implicated in cardiometabolic disease (CMD). Using vessels from mice and patients with CMD, we show that pharmacological …

Sickle cell anemia (SCA) is the most severe form of sickle cell disease and causes increased stroke risk, even in children. Hemodynamic mechanisms underlying cerebral vasculopathy remain unclear. To test the hypothesis that SCA causes disturbed flow and …

In the present study, a renewable resource-based, dynamically cross-linked hydrogel was developed using a combination of polyvinyl alcohol (PVA), lignin (LIG), and quercetin (QUE). LIG was extracted from peanut shells and served as a renewable …