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Endothelial Protective Effects of Ferulic Acid in Pre-eclampsia Treatment
Pre-eclampsia (PE) is a complex gestational disorder marked by vascular abnormalities and elevated blood pressure, yet remains without widely effective treatments. This study investigates the efficacy of Ferulic Acid (FA) in alleviating PE symptoms by …
Publication
Extracellular RNA as a molecular driver and therapeutic target in abdominal aortic aneurysms
Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammation, matrix degradation and smooth muscle cell (SMC) loss, leading to vessel dilation and rupture, with no current pharmaceutical management options. Since recent studies have …
Publication
Loss of ADAM17 in smooth muscle cells enhances their transformation to macrophage-like cells leading to more severe atherosclerosis in mice
Background & aims Atherosclerosis is a multicellular disease, and smooth muscle cells (SMCs) can contribute to plaque formation. ADAM17 (a distintegrin and metalloproteinase-17) is a membrane-bound proteinase that is upregulated in vascular disease and …
Publication
High-resolution three-dimensional quantitative photoacoustic and ultrasound imaging of subcutaneous microvasculature in extremities
Visualizing and monitoring morphological and functional information of microvasculature, including arterioles and venules, plays a crucial role in assessing vascular-related diseases. Clinical angiography methods have limitations in observing small …
Publication
Novel insights into the effects of JMV2894, a growth hormone secretagogue, in Duchenne muscular dystrophy: A preclinical study in the D2-mdx mouse model
Growth hormone secretagogues (GHSs) are gaining interest as promising therapeutics for Duchenne muscular dystrophy (DMD) due to their broad activity profile and proven benefits in other muscle-wasting conditions. We previously found that JMV2894 – a …
Publication
Elastase-2 deletion prevents vascular remodeling and abdominal aortic aneurysm development in a mice model induced by angiotensin II
Abdominal aortic aneurysm (AAA) involves the remodeling of the aortic wall extracellular matrix (ECM), compromising biomechanical support and increasing the risk of aortic dissection and rupture. Activation of the renin-angiotensin system (RAS), …
Publication
Maternal cholesterol deficiency predisposes congenital heart defects risk
The relationship between maternal cholesterol deficiency and the risk of congenital heart defects (CHDs) in offspring is not fully understood. In a birth cohort study of 5041 family trios, we found that low maternal cholesterol levels were significantly …
Publication
Photothermal Therapy Combined with Chemotherapy and Anti-Inflammation Therapy Weakens the Immunosuppression of Cervical Cancer
Background/Objectives: A non-toxic nano-platform which can increase drug-loading rate and synergistically increase antitumor effect is very ideal. This study provides the concept that a combination of photothermal therapy with chemotherapy and …
Publication
Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis
Terazosin (TZ), a well-known antagonist of the α1-adrenergic receptor (α1-AR), has demonstrated protective effects on vascular endothelial cells (ECs) and reduced vascular stiffness in clinical studies. Endothelial dysfunction and oxidative stress are …
Publication
Minimally Invasive Model of Mitral Regurgitation in Mice
Minimally Invasive Model of Mitral Regurgitation in Mice …