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Ultra High-Resolution Ultrasound Features of Carpal Tunnel Syndrome in Transthyretin Amyloidosis: A Cross-Sectional Study
Introduction/Aims: Transthyretin amyloidosis (ATTR), including hereditary (hATTR) and wild-type (wtATTR), often presents initially as carpal tunnel syndrome (CTS), often preceding systemic symptoms by several years. Ultra high-resolution ultrasound …
Publication
Breaking (Light) Barriers: Photoacoustics in Atherosclerotic Diseases
Photoacoustic imaging (PAI) is an emerging imaging modality that provides high-resolution, spatiotemporal insights into anatomical structures, functional parameters and molecular characteristics of tissues. By leveraging both endogenous absorbers, such as …
Publication
Rapid and Specific Cell-Surface Anchoring of Gold Nanostars for Photoacoustic BMSC Imaging
Background: Bone marrow mesenchymal stem cell (BMSC) therapy holds great promise for regenerative medicine, but its clinical translation is hindered by the lack of non-invasive, real-time methods to track transplanted cell fate in vivo. Although …
Publication
SSI-Net: a hybrid physics-constrained deep learning framework for quantitative ultrasound speed-of-sound reconstruction
Objective.Quantitative ultrasound tomography faces challenges in reconstructing speed-of-sound (SoS) distributions due to the ill-posed nature of the inverse problem and the computational complexity of full-waveform inversion. This study aims to develop …
Publication
Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models
Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, is closely linked to disturbed intracellular Ca2+ homeostasis. Visinin-like protein 1 (VILIP-1), newly identified in cardiomyocytes, has been implicated in modulating Ca2+ …
Publication
The impact of pericardial disruption on heart function and remodeling after myocardial infarction in mice
Myocardial infarction (MI) remains a leading cause of deaths globally. Thus, reliable and relevant animal MI models are crucial to understand underlying disease mechanisms and develop new therapies. Generally, MI in rodents is induced by ligation of the …
Publication
Close-to-Patient Models for Gastric Cancer: From Patient-Derived Xenograft Towards a Novel Gastric Cancer Mini-Tumor Model
Purpose: Gastric cancer (GC) is the fifth most lethal form of cancer. Because of its late diagnosis, high intratumor heterogeneity, and the presence of a dense stromal compartment, GC is less susceptible to systemic treatments compared to other tumor …
Publication
High-oxalate diet-induced kidney injury impairs AVF remodeling via hypertension, endothelial damage, and immune activation
BackgroundArteriovenous fistulas (AVF) are the preferred vascular access for hemodialysis, however patency rates remain low. Animal AVF models are essential for uncovering mechanisms of AVF remodeling. Yet most lack coexisting chronic kidney disease …
Publication
Microvascular endothelial scavenger receptor class B type I protects against heart failure with preserved ejection fraction by inhibiting T-cell cardiotropism
Cardiac microvascular endothelial cells (CMECs) dysfunction is a well-recognized mediator of heart failure with preserved ejection fraction (HFpEF), but the underlying mechanism remains unclear. Here we find that scavenger receptor class B type I (SR-B1) …
Publication
High- and Ultra-High-Frequency Ultrasound Identifies a Subclinical Link Between Suppurative Comedonal Nevus and Hidradenitis Suppurativa
Suppurative nevus comedonicus (SNC) is a variant of nevus comedonicus in which the characteristic features coexist with recurrent inflammatory lesions that clinically resemble those of hidradenitis suppurativa (HS). We present the ultrasound …