Acoustic angiography is a superharmonic contrast-enhanced ultrasound modality that maps 3-D microvasculature with fine spatial resolutions and has demonstrated potential to improve disease detection. However, the application of acoustic angiography for …

Lymph node (LN) metastasis remains a critical determinant of cancer progression and prognosis, yet surgical interventions result in adverse effects. In this preclinical study, we investigated a minimally invasive therapeutic approach combining magnetic …

Background: Increased pulmonary blood flow (IncPBF), one of the most important features of many children with congenital heart diseases, is well-known as a prerequisite for the induction of pulmonary arterial hypertension. However, due to the lack of …

Background: Coronary artery disease is a major cause of late mortality among childhood cancer survivors (CCS), but the prevalence of early vascular changes remains poorly defined. Objectives: The objective of the study was to evaluate early vascular …

Objective Ultrasound-targeted microbubble (MB) cavitation (UTMC) is an image-guided therapeutic oligonucleotide delivery platform utilizing intravenously injected gas-filled ultrasound contrast agents, which carry the therapeutic on the MB shell. During …

Introduction: Previous work from our group demonstrated that pregnant mice exposed to marijuana smoke presented reduced fetal and neonatal outcomes including reduced birthweight and increased placental weight. To further characterize the possible …

Cancer treatment remains challenging due to heterogeneous responses to immunotherapy across patients and tumor types. Innovative strategies are required to overcome immune evasion. We have identified the splicing factor SLU7 as essential for the survival …

Immune checkpoint inhibitors (ICI) benefit some cancer patients but de novo resistance remains poorly understood. Analyzing transcriptional data from two clinical trial cohorts, GO30140 and IMbrave150, we find B cell lymphoma 9 (BCL9), a Wnt/β-catenin …

Ovarian torsion (OT), a critical gynecological emergency caused by ovarian twisting and vascular compromise, risks necrosis without prompt intervention. This study evaluated dual-modal photoacoustic/ultrasound imaging for early detection and chronic …

Rupture of vulnerable atherosclerotic plaques is a major cause of acute cardiovascular events. Vascular smooth muscle cell (VSMC) senescence promotes plaque vulnerability by impairing fibrous cap integrity. Although melatonin exhibits atheroprotective …