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Photoactivated Gas-Generating Nanocontrast Agents for Long-Term Ultrasonic Imaging-Guided Combined Therapy of Tumors
To date, long-term and continuous ultrasonic imaging for guiding the puncture biopsy remains a challenge. In order to address this issue, a multimodality imaging and therapeutic method was developed in the present study to facilitate long-term ultrasonic …
Publication
Spleen-liver dual accumulation of ly6clowExo potentiates synergistic immune modulation for liver fibrosis therapy
Liver fibrosis (LF) afflicts millions of patients worldwide, yet a universally accepted standard therapy remains elusive. Notably, an elevation of profibrotic monocytes is observed in peripheral blood of LF patients. Inspired by the spleen's reported …
Publication
Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome
The transcriptional response to hypoxia is temporally regulated, yet the molecular underpinnings and physiological implications are unknown. We examined the roles of hepatic Bmal1 and Hif1α in the circadian response to hypoxia in mice. We found that the …
Publication
Targeting the PI3K/Akt/NF‐κB axis: Cluster of differentiation 5‐like‐mediated immunometabolic regulation of macrophage polarization in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a life‐threatening vascular disorder lacking effective pharmacological interventions. We identified CD5 molecule‐like (CD5L) as a regulator of macrophage polarization in AAA via the phosphoinositide 3‐kinase/protein …
Publication
Application of ultrasound in assessment of acute lung injury in mice
This study evaluated the effectiveness of non-invasive ultrasound technology in monitoring pulmonary edema in a mouse model of acute lung injury (ALI). Male C57BL/6J mice were instilled through the trachea with lipopolysaccharide (LPS, 5 mg/kg, single …
Publication
HSF1–DBC1 axis drives prostate cancer progression by activating a metastatic transcriptional program
Heat shock factor 1 (HSF1) is a key stress-protective transcription factor that acts as a guardian of proteostasis. HSF1 also plays multifaceted roles in tumor-associated processes including proliferation and metastasis. HSF1 is frequently overexpressed …
Publication
Fe-doped phase-transition nanodroplets for synergistic photothermal and starvation-enhanced ferroptosis in cancer therapy
BACKGROUND: Ferroptosis therapy has emerged as a promising antitumor strategy by utilizing the Fenton reaction to destroy cancer cells, where Fe2+ catalyzes the decomposition of H2O2 into hydroxyl radicals (•OH). Despite the great potential of ferroptosis …
Publication
Peripapillary scleral stiffening increases optic nerve head shear deformation in porcine eyes during IOP elevation
Computational models predicted that peripapillary sclera (PPS) stiffening may reduce intraocular pressure (IOP) induced stresses and strains at the optic nerve head (ONH). Experimental studies in animal models of glaucoma however did not confirm such …
Publication
Double gene overexpression of ZNF746 and cellular prion protein in rat adipose-derived mesenchymal stromal cell therapy protects the liver against ischemia‒reperfusion injury
This study presents an examination of whether the double overexpression of ZNF746 and cellular prion protein (PrPC) genes in rat adipose-derived mesenchymal stromal cells (ADMSCs) (ie, MSCDGe-OVE) offered enhanced protection to the livers of rats against …
Publication
Nelumbinis Plumula Attenuates High-Fat-induced Inflammation in Non-Alcoholic Fatty Liver Through The NOX/NF-κB Pathway
Nelumbinis Plumula Attenuates High-Fat-induced Inflammation in Non-Alcoholic Fatty Liver Through The NOX/NF-κB Pathway …