Introduction: Abdominal aortic aneurysm (AAA) is a chronic vascular disease marked by chronic inflammation and immune dysregulation. The C-C motif chemokine ligand 20 (CCL20) - C-C motif chemokine receptor type 6 (CCR6) axis modulates immune responses in …

Polydopamine nanoparticles (PDNPs) are a class of nanomaterials formed by the self-polymerization of dopamine. They exhibit high biocompatibility, biodegradability, antioxidant properties, and ease of functionalization and can serve as photothermal agents …

Abdominal aortic aneurysms (AAAs) are an age-related cause of sudden cardiac death and cardiovascular disease (CVD) morbidity with limited nonsurgical treatment options. In this issue of the JCI, Yonekawa et al. addressed the pathobiologic mechanisms of …

Despite advances in therapies for atherosclerosis, the limited efficacy in reversing vulnerable atherosclerotic plaques remains a significant challenge in translational cardiovascular research. We developed OPN-HMCN@MLT, a targeted nanoplatform combining …

Background: High- and ultra-high-frequency ultrasound (HFUS/UHFUS) may enhance early detection of clinically occult local recurrence at melanoma excision scars, where postoperative fibrotic or inflammatory changes can obscure subtle dermal–subcutaneous …

The axolotl is a popular model organism in regenerative biology owing to its ability to regenerate amputated limbs and internal organs. The role of injury-derived signals in initiating the regenerative response is still not well understood, but the …

Background: Diabetes mellitus is a major modifiable risk factor for atherosclerotic cardiovascular disease and pathological vascular remodeling. During chronic hyperglycemia, exosomes serve as essential nanocarriers that coordinate intercellular …

Complement- and inflammation-cascade activation-induced clearance of nanomedicines severely limits their efficacy in postoperative pain management. Here, we report a stealth nanomedicine (LMIBP) designed to directly address this challenge, enabling mild, …

Background Aortic aneurysm/dissection (AAD) is a catastrophic vascular emergency with limited therapeutic options and poorly understood molecular underpinnings. Ferroptosis, an iron-dependent form of regulated cell death, emerged as a crucial driver of …

The development of multimetallic nanoparticles for cancer treatment represents a significant advancement in the field of nanomedicine. We introduce a Cu-templated synthesis method to create AuxCuyPdz hollow nanomicrostructures, wherein gold atoms …