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The protective effect of maternal electroacupuncture on prenatal nicotine exposure-induced intrauterine growth restriction in rats by improving placental angiogenesis
Fetal intrauterine growth restriction (IUGR) is a common pregnancy complication that significantly impacts fetal health and long-term outcomes. Prenatal nicotine exposure (PNE) is a major environmental risk factor for IUGR, with abnormal placental …
Publication
PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites
Malignant serous effusion (MSE), including malignant pleural effusion (MPE) and malignant ascites (MA), is a common and severe complication in advanced malignancies, associated with poor prognosis and high recurrence rates. Currently, no standardized …
Publication
Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens
Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy …
Publication
Antitumor Activity of the Ethanolic Extract from Syzygium aromaticum in Colorectal Cancer Xenograft Mice
Background/Objectives: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, and the development of effective therapies with improved safety profiles is urgently needed. The hydrodistillation residue extract of Syzygium …
Publication
Longitudinal Ultrasound Imaging of an Individual Fetus In Utero Using an Echogenic Marker
Objective High frequency ultrasound imaging has become an important tool for the study of pregnancy disorders in mouse models as it enables detailed, noninvasive characterization of in utero development. However, the need to reliably identify individual …
Publication
Quantification of Kidney Inflammation Using Nanobubble-mediated Contrast Enhanced Ultrasound
Kidney inflammation is a central driver of acute kidney injury (AKI) and its progression to chronic kidney disease (CKD). While several imaging and biomarker-based approaches are under development, clinically validated non-invasive methods to directly …
Publication
Liposomal J-Aggregates of Indocyanine Green as a Multifunctional Contrast Agent for Photoacoustic Imaging and Photothermal Therapy
One of the major barriers to further clinical adoption of photoacoustic imaging (PAI) and photothermal therapy (PTT) is a lack of versatile and multi-faceted contrast agents. While indocyanine green (IcG) has gained considerable attention as a promising …
Publication
Enhanced Delivery of Lipid Nanoparticle-Based Immunotherapy by Modulating the Tumor Tissue Stiffness Using Ultrasound-Activated Nanobubbles
Tumors often exhibit an extracellular matrix with elevated stiffness due to excessive accumulation and cross-linking of proteins, particularly collagen. This elevated stiffness acts as a physical barrier, impeding the infiltration of immune cells and the …
Publication
Thrombospondin-4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance
Background and purpose: Extracellular matrix (ECM) remodelling is critical in abdominal aortic aneurysm (AAA), a life-threatening condition lacking effective pharmacotherapy. However, key ECM components regulating vascular integrity and remodelling remain …
Publication
Ultrasound-propelled oncolytic biomimetic microbubbles as in situ vaccines reprogram tumor immunosuppressive microenvironment
Oncolytic peptides offer a novel anticancer paradigm by inducing membrane lysis-mediated cancer cell death and subsequent anticancer immunity to overcome tumor heterogeneity and treatment resistance. Despite its promising profiles, the clinical …