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The Role of Ultra-High-Frequency Ultrasound in Pyoderma Gangrenosum: New Insights in Pathophysiology and Diagnosis
Pyoderma gangrenosum (PG) is a neutrophilic dermatological disease, whose pathogenesis is still poorly clarified. Because of the lack of validated criteria for diagnosis and response, PG treatment is still challenging and should be differentiated in the …
Publication
Feasibility of deep learning-based cancer detection in ultrasound microvascular images
Acoustic angiography is a superharmonic contrast-enhanced ultrasound modality that maps 3-D microvasculature with fine spatial resolutions and has demonstrated potential to improve disease detection. However, the application of acoustic angiography for …
Publication
Magnetic hyperthermia using iron oxide nanoparticles via LDDS suppressed lymph node and lung metastasis in a mouse model
Lymph node (LN) metastasis remains a critical determinant of cancer progression and prognosis, yet surgical interventions result in adverse effects. In this preclinical study, we investigated a minimally invasive therapeutic approach combining magnetic …
Publication
Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage
Background: Increased pulmonary blood flow (IncPBF), one of the most important features of many children with congenital heart diseases, is well-known as a prerequisite for the induction of pulmonary arterial hypertension. However, due to the lack of …
Publication
Vascular Health and Early Atherosclerosis in Childhood Cancer Survivors: Reassuring Findings From Comprehensive Noninvasive Assessment
Background: Coronary artery disease is a major cause of late mortality among childhood cancer survivors (CCS), but the prevalence of early vascular changes remains poorly defined. Objectives: The objective of the study was to evaluate early vascular …
Publication
Local Delivery of miR-27a* Using Ultrasound-Targeted Microbubble Cavitation Inhibits Squamous Cell Carcinoma Growth
Objective Ultrasound-targeted microbubble (MB) cavitation (UTMC) is an image-guided therapeutic oligonucleotide delivery platform utilizing intravenously injected gas-filled ultrasound contrast agents, which carry the therapeutic on the MB shell. During …
Publication
Marijuana smoking during pregnancy alters placenta morphology in BALB/c mice
Introduction: Previous work from our group demonstrated that pregnant mice exposed to marijuana smoke presented reduced fetal and neonatal outcomes including reduced birthweight and increased placental weight. To further characterize the possible …
Publication
Demonstration of SLU7 as a new cancer target
Cancer treatment remains challenging due to heterogeneous responses to immunotherapy across patients and tumor types. Innovative strategies are required to overcome immune evasion. We have identified the splicing factor SLU7 as essential for the survival …
Publication
Targeting tumor-intrinsic BCL9 reverses immunotherapy resistance by eliciting macrophage-mediated phagocytosis and antigen presentation
Immune checkpoint inhibitors (ICI) benefit some cancer patients but de novo resistance remains poorly understood. Analyzing transcriptional data from two clinical trial cohorts, GO30140 and IMbrave150, we find B cell lymphoma 9 (BCL9), a Wnt/β-catenin …
Publication
Dual-modal photoacoustic and ultrasound imaging for early diagnosis of ovarian torsion and evaluation of long-term tissue hypoxia
Ovarian torsion (OT), a critical gynecological emergency caused by ovarian twisting and vascular compromise, risks necrosis without prompt intervention. This study evaluated dual-modal photoacoustic/ultrasound imaging for early detection and chronic …