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CircEif3c/miR-96–5p/PHF20L1/MEOX2 axis in perivascular preadipocyte exosomes mediates fibroblast dysfunction and vascular remodeling
Background: Diabetes mellitus is a major modifiable risk factor for atherosclerotic cardiovascular disease and pathological vascular remodeling. During chronic hyperglycemia, exosomes serve as essential nanocarriers that coordinate intercellular …
Publication
Complement-inflammation inhibition via stealth nanomedicine for mild thermo-responsive postoperative on-demand pain management
Complement- and inflammation-cascade activation-induced clearance of nanomedicines severely limits their efficacy in postoperative pain management. Here, we report a stealth nanomedicine (LMIBP) designed to directly address this challenge, enabling mild, …
Publication
PHB2 ameliorates ferroptosis and aortic aneurysm/dissection through NEDD4L-dependent ubiquitination of NCOA4
Background Aortic aneurysm/dissection (AAD) is a catastrophic vascular emergency with limited therapeutic options and poorly understood molecular underpinnings. Ferroptosis, an iron-dependent form of regulated cell death, emerged as a crucial driver of …
Publication
Development of AuxCuyPdz Nanocomposites as Therapeutic Agents: Enhancing Cancer Treatment through Autophagy Modulation and Immune-Associated Effects
The development of multimetallic nanoparticles for cancer treatment represents a significant advancement in the field of nanomedicine. We introduce a Cu-templated synthesis method to create AuxCuyPdz hollow nanomicrostructures, wherein gold atoms …
Publication
Elevated asprosin in postmenopause is associated with vasculometabolic complications
Postmenopause is associated with increased adiposity, metabolic syndrome, and heightened cardiovascular disease (CVD) risk, yet the adipose-derived factors potentially contributing to vascular impairment remain poorly defined. Asprosin, a glucogenic …
Publication
Harnessing Ultrasound for Tumor Vascular Targeting: From Mechanistic Insights to Clinical Monitoring and Therapeutic Applications
The tumor vasculature, characterized by pathological angiogenesis and structural abnormalities, drives the progression of solid tumors by inducing hypoxia-acidosis microenvironments and therapeutic resistance. Targeting the tumor vasculature has emerged …
Publication
Introducing ARONG, A 3D Reconstruction Method for Highly Deformed Histology
Three-dimensional (3D) histopathology is an important expansion to histopathology, as a complete understanding of the 3D structure of tissues can lead to better diagnoses and treatments. For certain highly deformable tissues like carotid plaques, 3D …
Publication
Hemidesmosomes and Notch signaling regulate epidermal differentiation via delamination
Integrins mediate adhesion of basal keratinocytes to the underlying basement membrane. While high expression of integrins has been correlated with stemness, there is limited direct evidence that integrins mediate keratinocyte retention within the basal …
Publication
Flexible Ultrasound Patch for Noninvasive, Targeted Anti-Angiogenic Therapy of Unstable Carotid Plaques
Purpose: The growing global burden of ischemic stroke highlights the need for a deeper understanding of its pathogenic mechanisms. Although carotid plaque destabilization driven by intraplaque neovascularization is recognized as a critical factor of …
Publication
Mitochondrial Functional Capacity Is Impaired in Angiotensin II-Infused Mice and Not Recovered by Metformin
Background: The pathophysiological mechanisms of Abdominal Aortic Aneurysm (AAA) are not elucidated. Alterations in mitochondrial function, such as a reduction in oxidative phosphorylation (OXPHOS), have been observed at genome level and functionally in …