Guinea pigs have been a standard model in cardiovascular pharmacology and physiology research, but the advent of transgenic models has largely replaced them with mouse and rat models. However, guinea pigs remain important models in cardiac …

Previous studies have shown that Nox4 activates eIF2α/ATF4 signaling during the integrated stress response (ISR) and protects heart injury. However, their roles in calcific aortic valve disease (CAVD) remain unclear. Here, we show that both ATF4 and Nox4 …

This study investigates the molecular mechanisms of early stent placement intervention in mitigating neurovascular unit damage and cerebral microcirculatory disorder (CMD) associated with severe internal carotid artery stenosis (ICAS). By utilizing a rat …

Inflammation-driven injury, a significant source of morbidity and mortality worldwide, is largely mediated by the cytotoxic activities of neutrophils, which extend the initial lesion and jeopardize organ function. Intriguingly, inflammatory injury …

Most patients with hepatocellular carcinoma (HCC) develop resistance to immune checkpoint blockade (ICB) or STING agonists despite their immune-stimulating activities. Here, we identify increased intratumoral B-cell infiltration as a mediator of acquired …

Focal defects are one of the important features for the diagnosis of lymph node (LN) metastasis. In our previous study, an accurate method for detecting contrast agents was proposed. However, conventional B-mode and contrast-enhanced images via ultrasound …

Right ventricular (RV) adaptation critically determines survival in pulmonary hypertension (PH). Since cardiac fibroblasts (FBs) are crucial mediators of cardiac fibrosis, we aim to uncover the mechanism underlying their activation during RV remodeling. …

Parental obesity is associated with worsened cognitive performance and male-specific impairments in cardiac metabolism and function in AD-susceptible offspring, highlighting developmental programming as a modifier of heart-brain …

Tumor-associated macrophages (TAMs) are pivotal in the immunosuppressive tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC). The efficacy of targeting the CSF-1/CSF-1R axis in PDAC remains uncertain. Using single-cell RNA sequencing on …

We present a method for numerically determining the optimal wavelengths to perform spectral unmixing in photoacoustic experiments. The proposed method employs a rugged-landscape-model-inspired stochastic hill-climbing approach that can reliably and …