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Rare cases of plural breeding in captive and wild naked mole-rats: insights into social and reproductive dynamics
Plural breeding, the simultaneous reproduction of more than one female within a social group, is rarely observed in highly social mammals such as the naked mole-rat (Heterocephalus glaber), where reproduction is typically monopolized by a single dominant …
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A pilot study on midazolam sedation for murine echocardiography: A potential alternative to isoflurane anesthesia and awake imaging
Isoflurane anesthesia is often used to facilitate murine echocardiography, but can suppress cardiac function. Awake imaging avoids pharmacological interference, but can induce sympathetic activation. In this Midazolam sedation. Parameters were compared …
Publication
miR-155 suppresses angiotensin II type 1 receptor synthesis during placental morphogenesis
Several microRNAs play vital roles in placental development. miR-155 has been implicated in placental development and can directly interact with a variety of targets, including angiotensin type II receptor 1 (AT 1 R) ( Agtr1 ) mRNA. The AT 1 R is …
Publication
Prolonged exposure to nitrate in drinking water does not adversely impact prenatal or birth outcomes in a rat model
Nitrate (NO3−) is a common drinking water contaminant associated with increased risks of adverse pregnancy outcomes at concentrations below the World Health Organisation (WHO) drinking water guidelines (50 mg/L NO3−). However, causal evidence at relevant …
Publication
L19-Conjugated Gold Nanoparticles for the Specific Targeting of EDB-Containing Fibronectin in Neuroblastoma
Background/Objectives: Neuroblastoma (NB) is the most common extracranial solid tumor in children and accounts for 12–15% of pediatric cancer-related deaths. Current multimodal therapies lack specific cellular targets, causing systemic toxicity and drug …
Publication
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling
Real or simulated microgravity induces a senescence-like modification of carotid artery in both human and animal observations, with the mechanisms not fully elucidated. Here, we aim to elucidate the role of sterol regulatory element-binding protein 1 …
Publication
Solvent osmolarity and viscosity regulate lymph node pharmacokinetics and perinodal dynamics in lymphatic drug delivery
Solvent osmolarity and viscosity regulate lymph node pharmacokinetics and perinodal dynamics in lymphatic drug delivery …
Publication
Preparation and in vivo effectiveness evaluation of heparin-loaded PLGA@PCL core-shell fiber small-diameter vascular grafts
Cardiovascular disease has become the leading cause of death. It is the common goal for researchers worldwide to develop small-diameter vascular grafts (SDVGs) which could meet clinical needs. In this study, PLGA@PCL core-shell structural fibrous SDVGs …
Publication
Treatment of clonal hematopoiesis associated atherosclerosis via vaccine-based clearance of the mutant cells
Treatment of clonal hematopoiesis associated atherosclerosis via vaccine-based clearance of the mutant cells …
Publication
Preserved Function of Endothelial Colony-Forming Cells in Female Rats with Intrauterine Growth Restriction: Protection Against Arterial Hypertension and Arterial Stiffness?
Individuals born after intrauterine growth restriction (IUGR) are at increased risk of long-term cardiovascular complications, including elevated blood pressure, endothelial dysfunction, and arterial stiffness. Endothelial progenitor cells (EPCs), …