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Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states
Intratumor heterogeneity fundamentally challenges cancer treatment, as coexisting, molecularly distinct cell states with non-overlapping drug sensitivities can drive therapeutic resistance. We establish and validate a generalizable, network-based …
Publication
Cardiac metabolic remodeling drives dicarbonyl stress-induced mitochondrial dysfunction in experimental heart failure with preserved ejection fraction
Heart failure (HF) affects over 60 million people worldwide, with increasing prevalence as HF with preserved ejection fraction (HFpEF) among adults. Although metabolic remodeling and mitochondrial dysfunction are central features of HFpEF, the direct …
Publication
Diaphragm-specific effects of L-citrulline in mdx mice highlight its potential as adjuvant of standard therapy in Duchenne muscular dystrophy
Background and Purpose: The absence of the protein dystrophin in Duchenne muscular dystrophy (DMD) leads to progressive muscle weakness, failing regeneration and deregulation of nitric oxide (NO) signalling. We focused on L-citrulline, a precursor of …
Publication
H2S Donor Therapy Reverses Established Pulmonary Arterial Hypertension and Pulmonary Vascular Structural Remodeling in Rats
Objectives: Downregulation of the endogenous gasotransmitter hydrogen sulfide (H2S) contributes to the pathogenesis of pulmonary arterial hypertension (PAH). While prophylactic H2S supplementation prevents PAH initiation in different rat models, its …
Publication
Macrophage-derived CCL20 promotes abdominal aortic aneurysm progression via lymphocytes CCR6
Introduction: Abdominal aortic aneurysm (AAA) is a chronic vascular disease marked by chronic inflammation and immune dysregulation. The C-C motif chemokine ligand 20 (CCL20) - C-C motif chemokine receptor type 6 (CCR6) axis modulates immune responses in …
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Polydopamine Nanoparticles as Label-Free Contrast Agents in Photoacoustic Imaging In Vitro and In Vivo
Polydopamine nanoparticles (PDNPs) are a class of nanomaterials formed by the self-polymerization of dopamine. They exhibit high biocompatibility, biodegradability, antioxidant properties, and ease of functionalization and can serve as photothermal agents …
Publication
Expanding clones, expanding aneurysms through macrophage-to-osteoclast differentiation
Abdominal aortic aneurysms (AAAs) are an age-related cause of sudden cardiac death and cardiovascular disease (CVD) morbidity with limited nonsurgical treatment options. In this issue of the JCI, Yonekawa et al. addressed the pathobiologic mechanisms of …
Publication
A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques
Despite advances in therapies for atherosclerosis, the limited efficacy in reversing vulnerable atherosclerotic plaques remains a significant challenge in translational cardiovascular research. We developed OPN-HMCN@MLT, a targeted nanoplatform combining …
Publication
Ultra-High-Frequency Ultrasound of Melanoma Excision Scars for Detection of Clinically Occult Local Recurrence: A Single-Center Retrospective Study
Background: High- and ultra-high-frequency ultrasound (HFUS/UHFUS) may enhance early detection of clinically occult local recurrence at melanoma excision scars, where postoperative fibrotic or inflammatory changes can obscure subtle dermal–subcutaneous …
Publication
The adrenal stress response involves distinct dynamics of both cortisol and corticosterone in the axolotl salamander
The axolotl is a popular model organism in regenerative biology owing to its ability to regenerate amputated limbs and internal organs. The role of injury-derived signals in initiating the regenerative response is still not well understood, but the …