Venous thrombosis remains a major clinical challenge, with current therapeutic options limited by bleeding risks and procedural invasiveness. Here, it is demonstrated that static magnetic fields (SMFs) provide a non-invasive and effective strategy for …

Immunotherapy has shown a modest clinical benefit in advanced hepatocellular carcinoma (HCC), probably due to tumor immunosuppressive functions. Although Notch1 signaling has been implicated in tumor immune escape, its underlying mechanism is unclear. …

Background: Liver fibrosis is a crucial pathological stage in the progression of chronic liver diseases. Yiguanjian (YGJ), a Chinese herbal formula, exhibits anti-inflammatory, anti-fibrotic, and hepatoprotective effects. Extracellular vesicles from …

Purpose: To develop and validate photoacoustic imaging (PAI) as a method to assess hemoglobin counts and muscle tissue oxygen saturation in a mouse model of Sickle Cell Disease (SCD. Procedures: In vivo PAI was performed on mice with a SCD phenotype and …

Implantable Microdevices for In Vivo Assessment of Chemotherapy Response in Patient Derived Organoid Orthotopic Pancreatic Cancer …

We investigated the effects of early and postponed statin therapy after ovariectomy on the cardiovascular system in an experimental model of insulin resistance (hereditary hypertriglyceridemic rats). Thirty hereditary hypertriglyceridemic rats were …

Photothermal therapy (PTT) serves as a complementary strategy to conventional cancer treatments. Indocyanine green (ICG) is the only U.S. Food and Drug Administration (FDA)-approved photothermal agent. However, its clinical application is hindered by poor …

Background and Objective Ultrasound (US) is a widely used method for non-invasive tumor monitoring. Semantic segmentation of tumors in US imagery is a necessary step to reconstruct 3D geometry of a region of interest (ROI). Still, the segmentation task …

Biosynthesis of all androgens and estrogens from cholesterol requires CYP11A1 and CYP17A1. There is no known pathway in humans or other vertebrates that circumvents CYP17A1 for androgen or estrogen biosynthesis in physiology or disease. However, CYP17A1 …

Pulmonary congestion is a common complication in critically ill patients, but its quantification remains challenging. The wet-to-dry (W/D) lung weight ratio, widely used in experimental models, is a terminal and semi-quantitative method. Lung …