Ultrasound-guided selective occlusion of uteroplacental canal vessels in the mouse alters fetal growth and placental development

Using ultrasound-guidance, we can successfully occlude the placental canal arteries in a mouse, resulting in asymmetric growth, represented by an increase in brain-to-liver volume ratio, and decreased junctional zone volumes, which is apparent histologically and quantifiable via magnetic resonance imaging. In addition, survival rates for surgery are highly associated with the severity of uteroplacental impedance. This is the first study to our knowledge that has manipulated the uteroplacental circulation at the level of the intraplacental vessels.