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Amlodipine improves aortic dysfunction in atherosclerotic mice
Calcium channel blockers are established in treating hypertension or arrhythmias. They have also been suggested to have anti-atherosclerotic effects, although most such studies are limited mainly to histological or biochemical parameters. Therefore, the …
Publication
Inflammatory Factors Derived From Metabolic Dysfunction-Alcoholic Fatty Liver Disease: Inducers of Anxiety and Spatial Memory Impairment
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a global epidemic, with growing evidence suggesting its adverse impact on brain function. However, the underlying mechanisms linking hepatic metabolic dysfunction to …
Publication
Tumor necrosis factor alpha inhibition improves fetal growth in a rat model of preeclampsia
Introduction: Tumor necrosis factor alpha (TNF-α) is elevated 2-fold in women with preeclampsia. Preclinical investigation shows TNF-α blockade reduces maternal blood pressure in reduced uterine perfusion pressure (RUPP) rats and attenuates the reduction …
Publication
O-GlcNAcylation expression predicts a favorable prognosis and mitigates malignant phenotypes via MYCN suppression in neuroblastoma
Background: Neuroblastoma (NB) is a common pediatric malignancy originating from neural crest progenitor cells. While O-GlcNAcylation is known to regulate cancer cell metabolism and behavior, its specific role and prognostic value in neuroblastoma remain …
Publication
miRNA‑378a‑5p attenuates the development of abdominal aortic aneurysm via ABLIM1‑MKL1 signaling pathways
Abdominal aortic aneurysm (AAA) is a fatal cardiovascular disease with no effective drug treatment currently available. The aberrant expression levels of microRNAs (miRNAs or miRs) contribute to AAA pathogenesis. In the present study, miRNA microarray …
Publication
miR-210 overexpression increases pressure overload-induced cardiac fibrosis
Aortic stenosis, a common valvular heart disease, can lead to left ventricular pressure overload, triggering pro-fibrotic responses in the heart. miR-210 is a microRNA that responds to hypoxia and ischemia and plays a role in immune regulation and in …
Publication
Prostate specific membrane antigen-targeted multimodal imaging nanobubbles with ultrasound irradiation inhibit prostate cancer growth via autophagy activation
Ultrasound-targeted nanobubble destruction (UTND) is a promising noninvasive strategy for cancer treatment. However, off-target effects significantly influence UTND-mediated therapeutic efficacy and compromise accurate evaluation of tumors. …
Publication
Smooth Muscle Cell Specific Activity of SGK-1 Alters Aortic Stiffness and Abdominal Aortic Aneurysm Growth
Background/Objective: Activity of SGK-1 has been associated with mechanical aspects of vascular remodeling and matrix stiffening has been a known characteristic of AAA. We hypothesis that VSMC-specific SGK-1 activity is vital to growth of AAA and …
Publication
Spectral photoacoustic imaging of age-related reproductive tract collagen changes in a mouse model of prolapse
Monitoring collagen may help physicians assess female reproductive health, since altered collagen with age is an established risk factor for female reproductive disorders including pelvic organ prolapse. Currently, quantifying collagen in soft tissues …
Publication
Ultrasound-Triggered Nanobubbles for Endothelial-Targeted Drug Delivery in the Detection and Treatment of Doxorubicin-Induced Cardiotoxicity
Cardiotoxicity is a potential side effect of doxorubicin (DOX). However, there is a lack of effective methods for the timely detection and precise treatment of DOX-induced cardiotoxicity (DIC). Here, snRNA-seq of the hearts of patients with DIC and bulk …