Cross-species single-cell transcriptomic analysis unveils conserved myeloid signatures in abdominal aortic aneurysm: implications for therapeutic …

Postmenopause is associated with increased adiposity, metabolic syndrome, and heightened cardiovascular disease (CVD) risk, yet the adipose-derived factors potentially contributing to vascular impairment remain poorly defined. Asprosin, a glucogenic …

The tumor vasculature, characterized by pathological angiogenesis and structural abnormalities, drives the progression of solid tumors by inducing hypoxia-acidosis microenvironments and therapeutic resistance. Targeting the tumor vasculature has emerged …

Three-dimensional (3D) histopathology is an important expansion to histopathology, as a complete understanding of the 3D structure of tissues can lead to better diagnoses and treatments. For certain highly deformable tissues like carotid plaques, 3D …

Integrins mediate adhesion of basal keratinocytes to the underlying basement membrane. While high expression of integrins has been correlated with stemness, there is limited direct evidence that integrins mediate keratinocyte retention within the basal …

Purpose: The growing global burden of ischemic stroke highlights the need for a deeper understanding of its pathogenic mechanisms. Although carotid plaque destabilization driven by intraplaque neovascularization is recognized as a critical factor of …

A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome …

Background/Objectives: Accurate target delineation is critical in radiotherapy for head and neck non-melanoma skin cancer (NMSC), where tumor depth and subclinical extension are often underestimated by clinical and dermoscopic assessment alone. While high …

Background: The pathophysiological mechanisms of Abdominal Aortic Aneurysm (AAA) are not elucidated. Alterations in mitochondrial function, such as a reduction in oxidative phosphorylation (OXPHOS), have been observed at genome level and functionally in …

Pyoderma gangrenosum (PG) is a neutrophilic dermatological disease, whose pathogenesis is still poorly clarified. Because of the lack of validated criteria for diagnosis and response, PG treatment is still challenging and should be differentiated in the …