Background/Objective: Activity of SGK-1 has been associated with mechanical aspects of vascular remodeling and matrix stiffening has been a known characteristic of AAA. We hypothesis that VSMC-specific SGK-1 activity is vital to growth of AAA and …

Monitoring collagen may help physicians assess female reproductive health, since altered collagen with age is an established risk factor for female reproductive disorders including pelvic organ prolapse. Currently, quantifying collagen in soft tissues …

Cardiotoxicity is a potential side effect of doxorubicin (DOX). However, there is a lack of effective methods for the timely detection and precise treatment of DOX-induced cardiotoxicity (DIC). Here, snRNA-seq of the hearts of patients with DIC and bulk …

Introduction/Aims: Transthyretin amyloidosis (ATTR), including hereditary (hATTR) and wild-type (wtATTR), often presents initially as carpal tunnel syndrome (CTS), often preceding systemic symptoms by several years. Ultra high-resolution ultrasound …

Photoacoustic imaging (PAI) is an emerging imaging modality that provides high-resolution, spatiotemporal insights into anatomical structures, functional parameters and molecular characteristics of tissues. By leveraging both endogenous absorbers, such as …

Background: Bone marrow mesenchymal stem cell (BMSC) therapy holds great promise for regenerative medicine, but its clinical translation is hindered by the lack of non-invasive, real-time methods to track transplanted cell fate in vivo. Although …

Objective.Quantitative ultrasound tomography faces challenges in reconstructing speed-of-sound (SoS) distributions due to the ill-posed nature of the inverse problem and the computational complexity of full-waveform inversion. This study aims to develop …

The critical role of necroptosis in oil cyst formation associated with autologous fat transplantation …

Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, is closely linked to disturbed intracellular Ca2+ homeostasis. Visinin-like protein 1 (VILIP-1), newly identified in cardiomyocytes, has been implicated in modulating Ca2+ …

Myocardial infarction (MI) remains a leading cause of deaths globally. Thus, reliable and relevant animal MI models are crucial to understand underlying disease mechanisms and develop new therapies. Generally, MI in rodents is induced by ligation of the …