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High-resolution three-dimensional quantitative photoacoustic and ultrasound imaging of subcutaneous microvasculature in extremities
Visualizing and monitoring morphological and functional information of microvasculature, including arterioles and venules, plays a crucial role in assessing vascular-related diseases. Clinical angiography methods have limitations in observing small …
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Novel insights into the effects of JMV2894, a growth hormone secretagogue, in Duchenne muscular dystrophy: A preclinical study in the D2-mdx mouse model
Growth hormone secretagogues (GHSs) are gaining interest as promising therapeutics for Duchenne muscular dystrophy (DMD) due to their broad activity profile and proven benefits in other muscle-wasting conditions. We previously found that JMV2894 – a …
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Elastase-2 deletion prevents vascular remodeling and abdominal aortic aneurysm development in a mice model induced by angiotensin II
Abdominal aortic aneurysm (AAA) involves the remodeling of the aortic wall extracellular matrix (ECM), compromising biomechanical support and increasing the risk of aortic dissection and rupture. Activation of the renin-angiotensin system (RAS), …
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Maternal cholesterol deficiency predisposes congenital heart defects risk
The relationship between maternal cholesterol deficiency and the risk of congenital heart defects (CHDs) in offspring is not fully understood. In a birth cohort study of 5041 family trios, we found that low maternal cholesterol levels were significantly …
Publication
Photothermal Therapy Combined with Chemotherapy and Anti-Inflammation Therapy Weakens the Immunosuppression of Cervical Cancer
Background/Objectives: A non-toxic nano-platform which can increase drug-loading rate and synergistically increase antitumor effect is very ideal. This study provides the concept that a combination of photothermal therapy with chemotherapy and …
Publication
Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis
Terazosin (TZ), a well-known antagonist of the α1-adrenergic receptor (α1-AR), has demonstrated protective effects on vascular endothelial cells (ECs) and reduced vascular stiffness in clinical studies. Endothelial dysfunction and oxidative stress are …
Publication
Minimally Invasive Model of Mitral Regurgitation in Mice
Minimally Invasive Model of Mitral Regurgitation in Mice …
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Rare cases of plural breeding in captive and wild naked mole-rats: insights into social and reproductive dynamics
Plural breeding, the simultaneous reproduction of more than one female within a social group, is rarely observed in highly social mammals such as the naked mole-rat (Heterocephalus glaber), where reproduction is typically monopolized by a single dominant …
Publication
A pilot study on midazolam sedation for murine echocardiography: A potential alternative to isoflurane anesthesia and awake imaging
Isoflurane anesthesia is often used to facilitate murine echocardiography, but can suppress cardiac function. Awake imaging avoids pharmacological interference, but can induce sympathetic activation. In this Midazolam sedation. Parameters were compared …
Publication
miR-155 suppresses angiotensin II type 1 receptor synthesis during placental morphogenesis
Several microRNAs play vital roles in placental development. miR-155 has been implicated in placental development and can directly interact with a variety of targets, including angiotensin type II receptor 1 (AT 1 R) ( Agtr1 ) mRNA. The AT 1 R is …