Purpose: Gastric cancer (GC) is the fifth most lethal form of cancer. Because of its late diagnosis, high intratumor heterogeneity, and the presence of a dense stromal compartment, GC is less susceptible to systemic treatments compared to other tumor …

BackgroundArteriovenous fistulas (AVF) are the preferred vascular access for hemodialysis, however patency rates remain low. Animal AVF models are essential for uncovering mechanisms of AVF remodeling. Yet most lack coexisting chronic kidney disease …

Real-time photoacoustic imaging with freehand light delivery and augmented reality guidance …

Cardiac microvascular endothelial cells (CMECs) dysfunction is a well-recognized mediator of heart failure with preserved ejection fraction (HFpEF), but the underlying mechanism remains unclear. Here we find that scavenger receptor class B type I (SR-B1) …

Suppurative nevus comedonicus (SNC) is a variant of nevus comedonicus in which the characteristic features coexist with recurrent inflammatory lesions that clinically resemble those of hidradenitis suppurativa (HS). We present the ultrasound …

Intratumor heterogeneity fundamentally challenges cancer treatment, as coexisting, molecularly distinct cell states with non-overlapping drug sensitivities can drive therapeutic resistance. We establish and validate a generalizable, network-based …

Heart failure (HF) affects over 60 million people worldwide, with increasing prevalence as HF with preserved ejection fraction (HFpEF) among adults. Although metabolic remodeling and mitochondrial dysfunction are central features of HFpEF, the direct …

Background and Purpose: The absence of the protein dystrophin in Duchenne muscular dystrophy (DMD) leads to progressive muscle weakness, failing regeneration and deregulation of nitric oxide (NO) signalling. We focused on L-citrulline, a precursor of …

ALDOB K87 lactylation drives mitochondrial fission and metabolic reprogramming in pulmonary hypertension …

Objectives: Downregulation of the endogenous gasotransmitter hydrogen sulfide (H2S) contributes to the pathogenesis of pulmonary arterial hypertension (PAH). While prophylactic H2S supplementation prevents PAH initiation in different rat models, its …