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Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis.
Venous thromboembolism (VTE) is a common complication of cancer. Based on recent evidence that (i) Gas6 regulates the expression of tissue factor during venous thrombosis and (ii) cancer promotes a pro-coagulant milieu, we hypothesize that Gas6 may be …
Publication
Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive MiceSignificance
Objective—Hypercholesterolemia and hypertension are associated with aortic valve stenosis (AVS) in humans. We have examined aortic valve function, structure, and gene expression in hypercholesterolemic/hypertensive mice. Approach and Results—Control, …
Publication
Photodynamic Therapy Synergizes with Irinotecan to Overcome Compensatory Mechanisms and Improve Treatment Outcomes in Pancreatic Cancer
The ability of tumor cells to adapt to therapeutic regimens by activating alternative survival and growth pathways remains a major challenge in cancer therapy. Therefore, the most effective treatments will involve interactive strategies that target …
Publication
Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents : considerations on experimental outcomes and animal welfare
Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents : considerations on experimental outcomes and animal …
Publication
Compatibility of a Novel Thrombospondin-1 Analog with Fertility and Pregnancy in a Xenograft Mouse Model of Endometriosis
Endometriosis is a gynecological disease defined by the growth of endometrium outside of the uterus. Although endometriosis contributes to 50% of female infertility cases, medical treatments are incompatible with pregnancy. Angiogenesis, the growth of …
Publication
Transplacental sildenafil rescues lung abnormalities in the rabbit model of diaphragmatic hernia
Introduction The management of congenital diaphragmatic hernia (DH) would benefit from an antenatal medical therapy, which addresses both lung hypoplasia and persistent pulmonary hypertension. We aimed at evaluating the pulmonary effects of sildenafil in …
Publication
Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe
Photoacoustic tomography (PAT) of genetically encoded probes allows for imaging of targeted biological processes deep in tissues with high spatial resolution; however, high background signals from blood can limit the achievable detection sensitivity. Here …
Publication
Combined blockade of angiotensin II type 1 receptor and activation of peroxisome proliferator-activated receptor-?? by telmisartan effectively inhibits vascularization and growth of murine endometriosis-like lesions
STUDY QUESTION: Is telmisartan effective in the treatment of endometriosis?\n\nSUMMARY ANSWER: Combined blockade of angiotensin II type 1 receptor (AT1R) and activation of peroxisome proliferator-activated receptor (PPAR)-γ by telmisartan inhibits …
Publication
High-Resolution Ultrasound Imaging: A Novel Technique for the Noninvasive in Vivo Analysis of Endometriotic Lesion and Cyst Formation in Small Animal Models
Endometriosis, the presence of endometrial tissue at ectopic sites, is a highly prevalent gynecological dis- ease severely affecting a patient’s quality of life. To analyze the mechanisms involved in the disease and to identify new molecular targets for …
Publication
Cardiovascular Imaging in Mice
The mouse is the mammalian model of choice for investigating cardiovascular biology, given our ability to manipulate it by genetic, pharmacologic, mechanical, and environmental means. Imaging is an important approach to phenotyping both function and …