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High-resolution ultrasound biomicroscopy for monitoring ovarian structures in mice
BACKGROUND: Until recently, the limit of spatial resolution of ultrasound systems has prevented characterization of structures /= 20 microns develop in a wave-like fashion. CONCLUSION: The mouse is a suitable model for the study of ovarian dynamics using …
Publication
Tumor development, growth characteristics and spectrum of genetic aberrations in the TH-MYCN mouse model of neuroblastoma.
BACKGROUND: The TH-MYCN transgenic neuroblastoma model, with targeted MYCN expression to the developing neural crest, has been used to study neuroblastoma development and evaluate novel targeted tumor therapies.\n\nMETHODS: We followed tumor development …
Publication
A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies
Neuroblastoma, a childhood cancer that originates from neural crest-derived cells, is the most common deadly solid tumor of infancy. Amplification of the MYCN oncogene, which occurs in approximately 20–25% of human neuroblastomas, is the most prominent …
Publication
A comparison between detectors of high frequency oscillations
Objective—High frequency oscillations (HFOs) are a biomarker of epileptogenicity. Visual marking of HFOs is highly time-consuming and inevitably subjective, making automatic detection necessary. We compare four existing detectors on the same dataset. …
Publication
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma
Disabling the function of immune checkpoint molecules can unlock T-cell immunity against cancer, yet despite remarkable clinical success with monoclonal antibodies (mAb) that block PD-1 orCTLA-4, resistance remains common and essentially unex- plained. To …
Publication
Use of ultrasound biomicroscopy to evaluate induced ovarian follicular growth and ovulation in mice.
Recent advances in image technology, including significant gains in spatial resolution, have made realtime sequential ovarian evaluations possible in small rodents, allowing longitudinal (continued) studies of the ovarian cycle and reducing the required …
Publication
Quantitative volumetric imaging of normal, neoplastic and hyperplastic mouse prostate using ultrasound
Abstract Background: Genetically engineered mouse models are essential to the investigation of the molecular mechanisms underlying human prostate pathology and the effects of therapy on the diseased prostate. Serial in vivo volumetric imaging expands the …
Publication
Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer
// James Kalmuk 1, 4 , Margaret Folaron 1, 2 , Julian Buchinger 1, 5 , Roberto Pili 3 , Mukund Seshadri 1, 2 1 Department of Pharmacology and Therapeutics, Buffalo, NY, USA 2 Department of Molecular and Cellular Biophysics and Biochemistry, Buffalo, NY, …
Publication
Safety and Chemopreventive Effect of Polyphenon E in Preventing Early and Metastatic Progression of Prostate Cancer in TRAMP Mice.
Prostate cancer treatment is often accompanied by untoward side effects. Therefore, chemoprevention to reduce the risk and inhibit the progression of prostate cancer may be an effective approach to reducing disease burden. We investigated the safety and …
Publication
CHARACTERIZATION OF THYROID CANCER IN MOUSE MODELS USING HIGH-FREQUENCY QUANTITATIVE ULTRASOUND TECHNIQUES
Currently, the evaluation of thyroid cancer relies on the use of fine-needle aspiration biopsy, as noninvasive imaging methods do not provide sufficient levels of accuracy for the diagnosis of this disease. In this study, the potential of quantitative …