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A Direct Comparison of IV and ICV Delivery Methods for Gene Replacement Therapy in a Mouse Model of SMARD1
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is an infantile autosomal recessive disease caused by the loss of the ubiquitously expressed IGHMBP2 gene. SMARD1 causes degeneration of alpha-motor neurons, result- ing in distal muscle …
Publication
Alterations in Sod2-induced oxidative stress affect endocrine cancer progression
Although significant advances have been made in understanding the genetics of endocrine tumors, cellular physiology is relatively understudied as a determinant of tumor behavior. Oxidative stress (OS) and reactive oxygen species (ROS) are metabolic …
Publication
Evaluation of Intravascular Ultrasound Catheter-Based Transducers Using the Resolution Integral
Intravascular ultrasound (IVUS) catheters are a specialist imaging modality used in the assessment of cardiovascular disease. The ultrasound transducer may either be of single-element mechanical or phased-array design. Because of their design and …
Publication
Reduced myocyte complex N- glycosylation causes dilated cardiomyopathy
Protein glycosylation is an essential posttranslational modification that affects a myriad of physiologic processes. Humans with genetic defects in glycosylation, which result in truncated glycans, often present with significant cardiac deficits. Acquired …
Publication
Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux
Background: DRAM1 (Damage-regulated autophagy modulator 1) was reported as 1 one of the most important lysosome membrane protein that mediates the interaction between autophagosome and lysosome. Our aim was to investigate whether DRAM1 contributes to …
Publication
IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression
Background: The function of preadipocytes in the progression of early stage breast cancer has not been fully elucidated at the molecular level. To delineate the role of preadipocytes in breast cancer progression, we investigated the cross-talk between …
Publication
HIV transgene expression impairs K+ channel function in the pulmonary vasculature
Human immunodeficiency virus (HIV) infection is an established risk factor for pulmonary arterial hypertension (PAH), however the pathogenesis of HIV-related PAH remains unclear. Since K+ channel dysfunction is a common marker in most forms of PAH, our …
Publication
Adjustable photoacoustic tomography probe improves light delivery and image quality
One cause for suboptimal photoacoustic tomography (PAT) penetration depth is attenuation of incident light by soft tissue. To better understand this problem, we investigated the effects of illumination fiber optic bundle geometry on PAT penetration depth …
Publication
Facilitated Ca 2+ homeostasis and attenuated myocardial autophagy contribute to alleviation of diabetic cardiomyopathy after bariatric surgery
Bariatric surgery has been reported to relieve diabetic cardiomyopathy (DCM) effectively. However, the mechanisms remain largely unknown. To determine the effects of bariatric surgery on DCM via modulation of myocardial Ca2+ homeostasis and autophagy, …
Publication
Laser-activated perfluorocarbon nanodroplets: a new tool for blood brain barrier opening
A major obstacle in the monitoring and treatment of neurological diseases is the blood brain barrier (BBB), a semipermeable barrier that prevents the delivery of many therapeutics and imaging contrast agents to the brain. In this work, we explored the …