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Endothelial function is disturbed in a hypertensive diabetic animal model of HFpEF: Moderate continuous vs. high intensity interval training
Background: Heart failure with preserved ejection fraction (HFpEF) is associated with endothelial dysfunction, but the molecular mechanisms still remain unclear. Whether exercise training (ET) along with which optimal modality can improve endothelial …
Publication
Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model
Cardiac fibrosis is a pathological remodeling response to myocardial infarction (MI) and impairs cardiac contractility. Long noncoding RNA (lncRNA) metastasis‐ associated lung adenocarcinoma transcript 1 (MALAT1) is increased in patients with MI. However, …
Publication
Empagliflozin Increases Cardiac Energy Production in Diabetes
SGLT2 inhibitors have profound benefits on reducing heart failure and cardiovascular mortality in individuals with type 2 diabetes, although the mechanism(s) of this benefit remain poorly understood. Because changes in cardiac bioenergetics play a …
Publication
Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway
Aims: Cardiac hypertrophy is characterized by a shift in metabolic substrate utilization, but the molecular events underly- ing the metabolic remodelling remain poorly understood. We explored metabolic remodelling and mitochondrial dysfunction in cardiac …
Publication
The Dipeptidyl Peptidase-4 Substrate CXCL12 has Opposing Cardiac Effects in Young Mice and Aged Diabetic Mice Mediated By Ca 2+ Flux and Phosphoinositide 3-Kinase γ
Blood glucose lowering therapies can positively or negatively affect heart function in Type 2 diabetes, or they can have neutral effects. Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose by preventing the proteolytic inactivation of …
Publication
The two-pore-domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction
Cardiac two pore domain potassium channels (K2P) exist in organisms from Drosophila to humans, however their role in cardiac function is not known. We identified a K2P gene, CG8713 (sandman), in a Drosophila genetic screen and show that sandman is …
Publication
Adipose-derived cells improve left ventricular diastolic function and increase microvascular perfusion in advanced age
An early manifestation of coronary artery disease in advanced age is the development of microvascular dysfunction leading to deficits in diastolic function. Our lab has previously shown that epicardial treatment with adipose-derived stromal vascular …
Publication
Targeting Calpain for Heart Failure Therapy
Heart failure remains a major cause of morbidity and mortality in developed countries. There is still a strong need to devise new mechanism-based treatments for heart failure. Numerous studies have sug- gested the importance of the Ca2þ-dependent protease …
Publication
Subacute treatment of carprofen facilitate splenocardiac resolution deficit in cardiac injury
Inflammation-limiting nonsteroidal pain relievers magnify myocardial infarction (MI) incidences and increase re-admission events in heart failure (HF) patients.However, the molecular and cellu- lar mechanism of this provocative adverse effect is unclear. …
Publication
A catalase-loaded hierarchical zeolite as an implantable nanocapsule for ultrasound-guided oxygen self-sufficient photodynamic therapy against pancreatic cancer
Photodynamic therapy (PDT) is an alternative strategy for treating pancreatic cancer (PC) in clinics. However, the therapeutic efficacy is generally suppressed by inadequate oxygen supply in the hypoxic tumor microenvironment. Herein, hierarchical zeolite …