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4,4′-Methylenedianiline Alters Serotonergic Transport in a Novel, Sex-Specific Model of Pulmonary Arterial Hypertension in Rats
Pulmonary arterial hypertension (PAH) is a cardiovascular disorder characterized by elevated pulmonary artery pressure as a result of arterial wall thickening. Patients are 3-4 times more likely to be women than men. This gender discrepancy demonstrates a …
Publication
Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd - Skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis
Many genes, including odd-skipped related 1 (Osr1), are involved in regulation of mammalian kidney development. We describe here a new recessive mutation (kidney adysplasia and variable hydronephrosis, kavh) in the mouse that leads to downregulation of …
Publication
Assessment of ischaemia-reperfusion injury in the mice testis by using contrast ultrasound molecular imaging
Timely diagnosis of ischaemia–reperfusion (IR)-induced injury after testicular torsion may be critical for saving reproductive function. The purpose of this study was to detect IR-induced injury, indicated by E-selectin overexpression, in murine testis …
Publication
Age-related vascular gene expression profiling in mice
Increasing age involves a number of detrimental changes in the cardiovascular system and particularly on the large arteries. It deteriorates vascular integrity and leads to increased vascular stiffness entailing hypertension with increased cardiovascular …
Publication
Assessment of Venous Thrombosis in Animal Models
Deep vein thrombosis and common complications, including pulmonary embolism and post-thrombotic syndrome, represent a major source of morbidity and mortality worldwide. Experimental models of venous thrombosis have provided considerable insight into the …
Publication
Evaluation of Quantitative Imaging Biomarkers in the DSS Colitis Model
Purpose: In humans, colonoscopy is the gold standard for the diagnosis of inflammatory changes of the colon wall. Aim of this study was the identification of less invasive imaging biomarkers in the dextran sodium sulfate (DSS) colitis model to provide …
Publication
Squamous Cell Carcinoma Xenografts: Use of VEGFR2-targeted Microbubbles for Combined Functional and Molecular US to Monitor Antiangiogenic Therapy Effects
Purpose: To assess the ability of vascular endothelial growth factor receptor type 2 (VEGFR2)-targeted and nontargeted ultrasonography (US) to depict antiangiogenic therapy effects and to investigate whether first-pass kinetics obtained with VEGFR2- …
Publication
A New Acute Impact-Compression Lumbar Spinal Cord Injury Model in the Rodent
Traumatic injury to the lumbar spinal cord results in complex central and peripheral nervous tissue damage causing significant neurobehavioural deficits and personal/social adversity. Although lumbar cord injuries are common in humans, there are few …
Publication
Ascending Aortic Aneurysm in Angiotensin II-Infused Mice: Formation, Progression, and the Role of Focal Dissections.
OBJECTIVE To understand the anatomy and physiology of ascending aortic aneurysms in angiotensin II-infused ApoE(-/-) mice. APPROACH AND RESULTS We combined an extensive in vivo imaging protocol (high-frequency ultrasound and contrast-enhanced …
Publication
Axl modulates immune activation of smooth muscle cells in vein graft remodeling.
The pathophysiological mechanisms of the immune activation of smooth muscle cells are not well understood. Increased expression of Axl, a receptor tyrosine kinase, was recently found in arteries from patients after coronary bypass grafts. In the present …