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Publication
Radial artery intima-media thickness predicts major cardiovascular events in patients with suspected coronary artery disease
AIMS: In the present study, we investigated the prognostic value of radial artery intima-media thickness (rIMT) in patients with suspected coronary artery disease (CAD). Carotid artery intima-media thickness is a well-known surrogate marker of …
Publication
Increased Rate of Arterial Stiffening with Obesity in Adolescents: A Five-Year Follow-Up Study
BACKGROUND: We prospectively and longitudinally determined the effects of childhood obesity on arterial stiffening and vascular wall changes. Changes in arterial stiffness measured as pulse wave velocity (PWV) and vascular morphology of the radial (RA) …
Publication
Thicker carotid intima layer, thinner media layer and higher intima/media ratio in women with recurrent depressive disorders: A pilot study using non-invasive high frequency ultrasound
Objectives: Growing evidence indicates that depression is an important risk factor for coronary heart disease. Thus, the aim of the present study has been to investigate if young women with adolescent onset and recurrent depressive disorders have signs of …
Publication
Obese children show increased intimal wall thickness and decreased pulse wave velocity
OBJECTIVE: Childhood obesity confers an increased risk of vascular changes and adult cardiovascular disease. Using a high-resolution ultrasound technique that enables separation of intimal and medial layers, we examined the intimal thickness (IT) and …
Publication
The Rotterdam Radial Access Research
Background—Radial artery wall might be damaged after cannulation for cardiac catheterization. We investigated structural changes of the radial artery wall after catheterization to understand whether these might predict radial pulsation loss or occlusion …
Publication
Radiotherapy-related arterial intima thickening and plaque formation in childhood cancer survivors detected with very-high resolution ultrasound during young adulthood
PURPOSE: To test intensive alkylator-based therapy in desmoplastic small round-cell tumor (DSRCT). PATIENTS AND METHODS: Patients received the P6 protocol, which has seven courses of chemotherapy. Courses 1, 2, 3, and 6 included cyclophosphamide 4,200 …
Publication
Comparison of velocity vector imaging echocardiography with magnetic resonance imaging in mouse models of cardiomyopathy
BACKGROUND: Myocardial strain imaging using echocardiography can be a cost-effective method to quantify ventricular wall motion objectively, but few studies have compared strain measured with echocardiography against magnetic resonance imaging (MRI) in …
Publication
High-frequency speckle tracking echocardiography in the assessment of left ventricular function and remodeling after murine myocardial infarction
The objectives of this study were to assess the feasibility and accuracy of high-frequency speckle tracking echocardiography (STE) in a murine model of myocardial infarction (MI). STE is used clinically to quantify global and regional cardiac function, …
Publication
In vivo imaging reveals an essential role of vasoconstriction in rupture of the ovarian follicle at ovulation
Rupture of the ovarian follicle releases the oocyte at ovulation, a timed event that is critical for fertilization. It is not understood how the protease activity required for rupture is directed with precise timing and localization to the outer surface, …
Publication
Acoustic cavitation-based monitoring of the reversibility and permeability of ultrasound-induced blood-brain barrier opening
Cavitation events seeded by microbubbles have been previously reported to be associated with MR- or fluorescent-contrast enhancement after focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening. However, it is still unknown whether bubble …