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Sympathetic nervous remodeling is induced in the intermediolateral nucleus after myocardial infarction -Role of BDNF-TrkB axis-
Several studies have shown that neural remodeling in stellate ganglia (SG) is induced by myocardial infarction (MI). It remains unclear whether neural remodeling after MI is limited in SG within the sympathetic nervous system (SNS). MI was induced in a …
Publication
Exacerbation of dystrophic cardiomyopathy by phospholamban deficiency-mediated chronically increased cardiac Ca 2+ cycling in vivo
Cardiomyopathy is a significant contributor to morbidity and mortality in Duchenne Muscular Dystrophy (DMD). Membrane instability, leading to intracellular calcium (Ca2+) mishandling and overload, causes myocyte death and subsequent fibrosis in DMD …
Publication
Dysfunctional and Pro-Inflammatory Regulatory T-Lymphocytes are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy
Background: Heart failure (HF) is a state of inappropriately sustained inflammation, suggesting the loss of normal immunosuppressive mechanisms. Regulatory T-lymphocytes (Tregs) are considered key suppressors of immune responses; however, their role in HF …
Publication
Cyclopeptide COR-1 to treat beta1-adrenergic receptor antibody-induced heart failure
Rationale Despite advances in pharmacotherapy, heart failure still incurs significant morbidity and mortality. Stimulating antibodies directed against the secondextracellular loop of the human ß1-adrenergic receptor (anti-ß1EC2) cause myocyte damage and …
Publication
A cerebellar window for intravital imaging of normal and disease states in mice
The cerebellum is a prominent part of the vertebrate hindbrain that is critically involved in the regulation of important body functions such as movement coordination, maintenance of balance and posture, and motor control. Here, we describe a cerebellar …
Publication
Increased myocardial stiffness activates cardiac microvascular endothelial cell via VEGF paracrine signaling in cardiac hypertrophy
When the heart is subjected to an increased workload, mechanical stretch together with neurohumoral stimuli activate the “fetal gene program” and induce cardiac hypertrophy to optimize output. Due to a lack of effective methods/models to quantify and …
Publication
MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma
Glioblastoma multiforme (GBM) is the most common and highly malignant primary brain tumor, which is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. To develop novel therapeutic approaches for treatment of GBM, we …
Publication
Cilostazol ameliorates heart failure with preserved ejection fraction and diastolic dysfunction in obese and non-obese hypertensive mice
Cilostazol (Ciloz) a potent Type III phosphodiesterase inhibitor is effective against inflammation, insulin resistance and cardiomyopathy. However, the effect of Ciloz on obesity-associated left ventricular diastolic dysfunction has not been explored yet. …
Publication
Improving Stem Cell Delivery to the Trabecular Meshwork Using Magnetic Nanoparticles
Glaucoma is a major cause of blindness and is frequently associated with elevated intraocular pressure. The trabecular meshwork (TM), the tissue that primarily regulates intraocular pressure, is known to have reduced cellularity in glaucoma. Thus, stem …
Publication
Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment
Background: Central nervous system (CNS) metastases represent a major problem in the treatment of human epidermal growth factor receptor 2 (HER2)–positive breast cancer because of the disappointing efficacy of HER2-targeted therapies against brain …