Listen to the Light: Visualizing Deep Optical Signals with High Resolution! PA-Mode Single Wavelength allows the detection and fusion of photoacoustic signals with detailed anatomical images. Using a tuneable near infrared laser, the subject is …

Spinal cord injury (SCI) is a devastating condition that results in whole-body dysfunction, notably cardiovascular (CV) disruption and disease. Injury- induced destruction of autonomic pathways in conjunction with a progressive decline in physical fitness …

Tissue-mimicking materials (TMMs) are widely used in quality assurance (QA) phantoms to assess the performance of ultrasound scanners. The International Electrotechnical Commission (IEC) defines the acoustic parameters of up to 10 MHz. To manufacture a …

Introduction: Wound healing after myocardial infarction (MI) is mediated by different cell types, secreted proteins, components of the extracellular matrix (ECM) and, as increasing evidences suggest, extracellular vesicles (EVs). We aim to determine the …

Background: In the heart, slow delayed rectifier channels provide outward currents (IKs) for action potential (AP) repolarization in a region- and context-dependent manner. In diseased hearts, chronic elevation of angiotensin II (Ang II) may remodel IKs …

In efforts to improve solid tumor imaging, and enable image-guided drug delivery (IGDD), multiple types of clinical imaging modalities have been combined with nanoparticle platforms1,2. These have improved ability to understand tumor microenvironment and …

The advantage of multispectral imaging is in being able to distinguish optically differing signals from each other. Take advantage of the tuneability of the laser source in order to rapidly acquire photoacoustic data at multiple wavelengths in 2D and 3D …

Mitophagy eliminates dysfunctional mitochondria and thus plays a cardinal role in diabetic cardiomyopathy (DCM). We observed the favourable effects of melatonin on cardiomyocyte mitophagy in mice with DCM and elucidated their underlying mechanisms. …

Heart failure is associated with low cardiac output (CO) and low brain perfusion that imposes a significant risk for accelerated brain aging and Alzheimer disease development. Although clinical heart failure can emerge several years following acute …

Metastasis is the leading cause of cancer-related deaths. A number of chemotherapeutic and early diagnosis strategies, including nanomedicine, have been developed to target metastatic tumor cells. However, simultaneous inhibition and imaging of metastasis …