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Disseminated injection of vincristine-loaded silk gel improves the suppression of neuroblastoma tumor growth
Background: Advanced-stage neuroblastoma patients require multiagent chemotherapy. Intratumoral implantation of vincristine-loaded silk gel uses local diffusion to decrease orthotopic neuroblastoma tumor growth in mice. We hypothesize that injecting …
Publication
Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation
Dilated cardiomyopathy (DCM) is a severe disorder caused by medications or genetic mutations. D5 dopamine receptor (D5R) gene knockout (D5-/-) mice have cardiac hypertrophy and high blood pressure. To investigate the role and mechanism by which the D5R …
Publication
Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure
Heart failure (HF) is a shared manifestation of several cardiovas- cular pathologies, including hypertension and myocardial infarc- tion, and a limited repertoire of treatment modalities entails that the associated morbidity and mortality remain high. …
Publication
Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Chronic Ethanol-induced Cardiac Fibrosis by Restoring Autophagic Flux
BACKGROUND: Chronic drinking leads to myocardial contractile dysfunction and dilated cardiomyopathy, and cardiac fibrosis is a consequence of these alcoholic injuries. Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids to less bioactive …
Publication
Comparative determination of placental perfusion by magnetic resonance imaging and contrast-enhanced ultrasound in a murine model of intrauterine growth restriction
Introduction: Exploration of placental perfusion is essential in screening for dysfunctions impairing fetal growth. The objective of this study was to assess the potential value of contrast-enhanced ultrasonography (CEUS) and magnetic resonance imaging …
Publication
Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor, decorin
The extracellular matrix is a master regulator of tissue homeostasis in health and disease. Here we examined how the small, leucine-rich extracellular matrix proteoglycan, decorin, regulates cardiomyocyte metabolism during fasting in vivo. First, we …
Publication
Prevascularization of dermal substitutes with adipose tissue-derived microvascular fragments enhances early skin grafting
Split-thickness skin grafts (STSG) are still the gold standard for the treatment of most skin defects. Hence, there is an ongoing need to improve this procedure. For this purpose, we herein analyzed dermal matrices seeded with adipose tissue-derived …
Publication
A novel animal model for residence time evaluation of injectable hyaluronic acid-based fillers using high-frequency ultrasound-based approach
Background: Hyaluronic acid (HA)-based devices are among the most popular filler agents for skin rejuvenation. One of the principal goals is the improvement in residence time of HA-based products, to increase their performance and reduce frequency of the …
Publication
A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder
Chronic kidney disease (CKD) is associated with mineral and bone disorder (MBD), which is the main cause of the extensively increased cardiovascular mortality in the CKD population. We now aimed to establish a new murine experimental CKD-MBD model. Dilute …
Publication
Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney
The balance between adaptive and innate immunity in kidney damage in salt-dependent hypertension is unclear. We investigated early renal dysfunction and the influence of Axl, a receptor tyrosine kinase, on innate immune response in hypertensive kidney in …