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Heat-shock transcription factor 1 is critically involved in the ischaemia-induced cardiac hypertrophy via JAK2/STAT3 pathway
Cardiac hypertrophy after myocardial infarction (MI) is an independent risk factor for heart failure. Regression of cardiac hypertrophy has emerged as a promising strategy in the treatment of MI patients. Here, we have been suggested that heat- shock …
Publication
Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity
Background-—Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological …
Publication
Sex Differences in Depression-Like Behavior and Neuroinflammation in Rats Post MI: Role of Estrogens
Patients with heart failure (HF) have a high prevalence of depression associated with a worse prognosis, particularly in older women. This study evaluated whether sex and estrogens affect depression-like behavior and associated neuroinflammation induced …
Publication
Immune response mediates cardiac dysfunction after traumatic brain injury
Cardiovascular complications are common after TBI and are associated with increased morbidity and mortality. In this study, we investigated the possible role of the immune system in mediating cardiac dysfunction post-TBI in mice. Adult male C57BL/6J mice …
Publication
A biodegradable synthetic graft for small arteries matches the performance of autologous vein in rat carotid arteries
Autologous veins are the most widely used grafts for bypassing small arteries in coronary and peripheral arterial occlusive diseases. However, they have limited availability and cause donor- site morbidity. Here, we report a direct comparison of acellular …
Publication
The role of Parkin protein in cardiac function and ventricular remodeling in myocardial infarction rats
OBJECTIVE: This study aims to ex- plore the role and the mechanism of Parkin pro- tein in cardiac function and ventricular remodel- ing in myocardial infarction (MI) rats, and to pro- vide a new sight for the treatment of myocardi- al infarction. …
Publication
The Murine Dialysis Fistula Model Exhibits a Senescence Phenotype: Pathobiologic Mechanisms and Therapeutic Potential
There is no therapy that promotes maturation and functionality of a dialysis arteriovenous fistula (AVF). The search for such therapies largely relies on evaluating vascular responses and putative therapies in experimental AVFs. We studied an AVF in mice …
Publication
CAVEOLIN-3 KO DISRUPTS T-TUBULE STRUCTURE AND DECREASES T-TUBULAR I Ca DENSITY IN MOUSE VENTRICULAR MYOCYTES
Caveolin-3 (Cav-3) is a protein that has been implicated in t-tubule formation and function in cardiac ventricular myocytes. In cardiac hypertrophy and failure, Cav-3 expression decreases, t-tubule structure is disrupted and excitation-contraction …
Publication
The involvement of AQP1 in myocardial edema induced by pressure overload in mice
OBJECTIVE: To investigate the effect of aquaporin-1 (AQP1) on heart edema in- duced by transverse aortic constriction (TAC) in mice, and to explore whether inhibiting the ex- pression of AQP1 could attenuate myocardial edema and improve cardiac function. …
Publication
Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo
Photoacoustic (PA) computed tomography (PACT) benefits from genetically encoded probes with photochromic behavior, which dramatically increase detection sensitivity and specificity through photoswitching and differential imaging. Starting with a DrBphP …