Search
Publication
Photodynamic immune stimulation eradicates primary pigmented melanoma and induces long-lasting anti-tumor immunity
Background: Melanoma is highly aggressive with limited options in advanced disease. Photodynamic therapy (PDT) has shown poor efficacy in pigmented melanoma due to restricted light penetration and intrinsic ROS resistance. A novel approach is investigated …
Publication
Magnetothermal Wax Capsule for Localized Gastrointestinal Drug Delivery
Oral drug delivery to gastrointestinal (GI) lesions remains challenging, as current systems rely on physiological triggers such as pH, enzymes, and luminal pressure, which vary widely among patients. To address this, an ingestible capsule was developed to …
Publication
Dexmedetomidine enhances ultrasound-guided sciatic nerve block in rats by reducing perineural capillary permeability via RhoA/ROCK-MLC signaling
Dexmedetomidine (DEX) is widely used as an adjuvant to local anesthetics to prolong the duration of nerve block-induced analgesia. Despite its clinical efficacy, the precise mechanisms by which DEX enhances and extends analgesic effects remain …
Publication
Protocol to prepare PARPi-combined LIN28B siRNA nanoparticles and evaluate therapeutic efficacy of malignant ascites
Malignant serous effusion (MSE) is a life-threatening complication of advanced cancers with limited effective treatments. Here, we present a protocol for the preparation of LIN28B siRNA-loaded nanoparticles and their combination with PARP inhibition for …
Publication
Cocktail Therapy Combining SGLT2 Inhibitor, Entresto, and Adipose-Derived Mesenchymal Stem Cells Prevents Abdominal Aortic Aneurysmal Complication Syndrome in Rodents
Background: This study investigated whether triple combination therapy [dapagliflozin (DAPA) + sacubitril/valsartan (Entresto) + adipose-derived mesenchymal stem cells (ADMSCs)] offered additional benefits on preventing complication syndrome [defined as …
Publication
Combined ethanol and lauromacrogol sclerotherapy for ovarian endometriotic cysts: a retrospective clinical and experimental study
Combined ethanol and lauromacrogol sclerotherapy for ovarian endometriotic cysts: a retrospective clinical and experimental study …
Publication
HDACs-targeting photosensitizer-based local-therapy augmenting photoimmunotherapy in bladder cancer
Immune checkpoint inhibitors (ICIs) represent a promising therapeutic strategy in bladder cancer (BCa), while limited response rates as monotherapy significantly restrict clinical application. To address this, we prepared QTANHOH, a quinoxalinone-based …
Publication
Intratumoral therapeutic dust for chemo-photodynamic combination treatment
Implantable wireless ultrasound microdevices for intratumoral therapy are hindered by inadequate miniaturiza-tion for deep-seated sites and toxic lead-based piezoelectrics. Here, we report an injectable, lead-free, submillime-ter therapeutic dust …
Publication
Engineering Gold Nanoconstruct Architecture Dictates Absorption Efficiency and Photoacoustic Imaging Performance
Photoacoustic (PA) imaging combines the high contrast of optical modalities with the deep-tissue penetration and high-spatial resolution of ultrasound, making it an attractive technique for biomedical imaging. Gold nanoconstructs are among the most widely …
Publication
Cardiac Adaptation in a Murine Iliac Arteriovenous Fistula Model and the Impact of Sex and N-Acetylcysteine Supplementation
Hemodialysis arteriovenous fistulas(AVFs) promote left ventricular(LV) hypertrophy, a known predictor of cardiovascular mortality in patients with chronic kidney disease(CKD). AVF flow dynamics do not reliably predict cardiac remodeling suggesting …