Oncolytic peptides offer a novel anticancer paradigm by inducing membrane lysis-mediated cancer cell death and subsequent anticancer immunity to overcome tumor heterogeneity and treatment resistance. Despite its promising profiles, the clinical …

Reception of conspecific cues alters testicular gene expression and improves fertility in boreal chorus frogs (Pseudacris maculata) …

Calcium channel blockers are established in treating hypertension or arrhythmias. They have also been suggested to have anti-atherosclerotic effects, although most such studies are limited mainly to histological or biochemical parameters. Therefore, the …

Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a global epidemic, with growing evidence suggesting its adverse impact on brain function. However, the underlying mechanisms linking hepatic metabolic dysfunction to …

Introduction: Tumor necrosis factor alpha (TNF-α) is elevated 2-fold in women with preeclampsia. Preclinical investigation shows TNF-α blockade reduces maternal blood pressure in reduced uterine perfusion pressure (RUPP) rats and attenuates the reduction …

Background: Neuroblastoma (NB) is a common pediatric malignancy originating from neural crest progenitor cells. While O-GlcNAcylation is known to regulate cancer cell metabolism and behavior, its specific role and prognostic value in neuroblastoma remain …

Abdominal aortic aneurysm (AAA) is a fatal cardiovascular disease with no effective drug treatment currently available. The aberrant expression levels of microRNAs (miRNAs or miRs) contribute to AAA pathogenesis. In the present study, miRNA microarray …

Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect …

Aortic stenosis, a common valvular heart disease, can lead to left ventricular pressure overload, triggering pro-fibrotic responses in the heart. miR-210 is a microRNA that responds to hypoxia and ischemia and plays a role in immune regulation and in …

Ultrasound-targeted nanobubble destruction (UTND) is a promising noninvasive strategy for cancer treatment. However, off-target effects significantly influence UTND-mediated therapeutic efficacy and compromise accurate evaluation of tumors. …