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An Intraperitoneal Injection Technique in Adult Zebrafish that Minimizes Body Damage and Associated Mortality
The adult zebrafish (Danio rerio), which is genetically accessible, is being employed as a valuable vertebrate model to study human disorders such as cardiomyopathy. Intraperitoneal (IP) injection is an important method that delivers compounds to the body …
Publication
Ultrasound Patterns of Vitiligo at High Frequency and Ultra-High Frequency
Objectives: To detect ultrasonographic anatomical alterations in all the skin layers in patients with vitiligo. Methods: A prospective observational color Doppler ultrasound study was performed in nonsegmental face and/or neck vitiligo patients without a …
Publication
Docetaxel-Encapsulated Catalytic Pt/Au Nanotubes for Synergistic Chemo-Photothermal Therapy of Triple-Negative Breast Cancer
The combination of photothermal therapy with chemotherapy has emerged as a promising therapeutic modality for addressing triple-negative breast cancer (TNBC). This manuscript describes a novel hybrid nanoplatform comprising ultrathin catalytic …
Publication
Photoactivated Gas-Generating Nanocontrast Agents for Long-Term Ultrasonic Imaging-Guided Combined Therapy of Tumors
To date, long-term and continuous ultrasonic imaging for guiding the puncture biopsy remains a challenge. In order to address this issue, a multimodality imaging and therapeutic method was developed in the present study to facilitate long-term ultrasonic …
Publication
Spleen-liver dual accumulation of ly6clowExo potentiates synergistic immune modulation for liver fibrosis therapy
Liver fibrosis (LF) afflicts millions of patients worldwide, yet a universally accepted standard therapy remains elusive. Notably, an elevation of profibrotic monocytes is observed in peripheral blood of LF patients. Inspired by the spleen's reported …
Publication
Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome
The transcriptional response to hypoxia is temporally regulated, yet the molecular underpinnings and physiological implications are unknown. We examined the roles of hepatic Bmal1 and Hif1α in the circadian response to hypoxia in mice. We found that the …
Publication
Targeting the PI3K/Akt/NF‐κB axis: Cluster of differentiation 5‐like‐mediated immunometabolic regulation of macrophage polarization in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a life‐threatening vascular disorder lacking effective pharmacological interventions. We identified CD5 molecule‐like (CD5L) as a regulator of macrophage polarization in AAA via the phosphoinositide 3‐kinase/protein …
Publication
Application of ultrasound in assessment of acute lung injury in mice
This study evaluated the effectiveness of non-invasive ultrasound technology in monitoring pulmonary edema in a mouse model of acute lung injury (ALI). Male C57BL/6J mice were instilled through the trachea with lipopolysaccharide (LPS, 5 mg/kg, single …
Publication
HSF1–DBC1 axis drives prostate cancer progression by activating a metastatic transcriptional program
Heat shock factor 1 (HSF1) is a key stress-protective transcription factor that acts as a guardian of proteostasis. HSF1 also plays multifaceted roles in tumor-associated processes including proliferation and metastasis. HSF1 is frequently overexpressed …
Publication
Fe-doped phase-transition nanodroplets for synergistic photothermal and starvation-enhanced ferroptosis in cancer therapy
BACKGROUND: Ferroptosis therapy has emerged as a promising antitumor strategy by utilizing the Fenton reaction to destroy cancer cells, where Fe2+ catalyzes the decomposition of H2O2 into hydroxyl radicals (•OH). Despite the great potential of ferroptosis …