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An autofluorescence-based method for the isolation of highly purified ventricular cardiomyocytes
AIMS: The aim of our study was to set up a simple and reliable isolation method of living ventricular cardiomyocytes (vCMs) for molecular and biological studies. METHODS: A standard technique for the retrograde perfusion of an enzymatic solution was used …
Publication
Hemispherical photoacoustic imaging of myocardial infarction: in vivo detection and monitoring
Objectives: This study aimed to demonstrate the capacity for noninvasive localisation and characterisation of myocardial infarction (MI) in vivo using a hemispherical photoacoustic imaging (PAI) system. MI remains a leading cause of morbidity and …
Publication
Pazopanib for renal cell carcinoma leads to elevated mean arterial pressures in a murine model
Background: In the setting of metastatic RCC (mRCC), pazopanib is approved as first line therapy. Unfortunately treatment may lead to cardiotoxicity such as hypertension, heart failure, and myocardial ischemia. Objective: Define the in vivo role of …
Publication
Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway
Reducing oxidative stress is a crucial therapeutic strategy for ameliorating diabetic myocardial ischemia/reperfusion (MI/R) injury. Honokiol (HKL) acts as an effective cardioprotective agent for its strong antioxidative activity. However, its roles and …
Publication
Overexpression of microRNA-145 protects against rat myocardial infarction through targeting PDCD4
Myocardial infarction (MI) is a common cardiovascular disease with high mortality. The aim of the present study was to determine the biological role of miR-145 in MI rats and hypoxia-injured cardiomyocytes and to eluci- date the potential mechanism. MI …
Publication
Lung function and pulmonary artery blood flow following prenatal maternal retinoic acid and imatinib in the nitrofen model of congenital diaphragmatic hernia
Background: Lung and pulmonary vascular maldevelopment in congenital diaphragmatic hernia (CDH) results in significant morbidity and mortality. Retinoic acid (RA) and imatinib have been shown to improve pulmonary morphology following prenatal …
Publication
Effect of myostatin deletion on cardiac and microvascular function
The objective of this study is to test the hypothesis that increased muscle mass has positive effects on cardiovascular function. Specifically, we tested the hypothesis that increases in lean body mass caused by deletion of myostatin improves cardiac …
Publication
Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection
Immune cells are equipped with a number of recep- tors that recognize sterile injury and pathogens. We find that host immune cells release ATP as an inflam- matory signal in response to allogeneic transplanta- tion. ATP then acts via a feedback mechanism …
Publication
Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury
MicroRNA-based therapies that target cardiomyocyte proliferation have great potential for the treatment of myocardial infarction. In previous work, we showed that the miR-302/367 cluster regulates cardiomyocyte proliferation in the prenatal and postnatal …
Publication
Uterine Artery Flow and Offspring Growth in Long-Evans Rats following Maternal Exposure to Ozone during Implantation
BACKGROUND: Epidemiological studies suggest that increased ozone exposure during gestation may compromise fetal growth. In particular, the im- plantation stage of pregnancy is considered a key window of susceptibility for this outcome. OBJECTIVES: The …