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Publication
Heterogeneous tumor blood oxygenation dynamics during phototherapy deciphered with real-time label-free photoacoustic imaging
Understanding the heterogeneity of tumor vascular function and oxygenation is key in individualizing treatments, especially with therapies that are ineffective in hypoxic microenvironments. Our previous work has demonstrated that ultrasound-guided …
Publication
In vivo quantification of collagen-induced arthritis mouse model by three-dimensional volumetric ultrasound and color Doppler
Purpose Ultrasound combined with Doppler techniques has been widely utilized to evaluate joint inflammation and internal structural changes in animal models of rheumatoid arthritis. However, previous assessments using these techniques were predominantly …
Publication
Free gas micro-/nano-bubble water: A novel dispersion system to prepare ultrasound imaging vehicles
Free gas micro-/nano-bubbles (MNBs) in water have demonstrated significant potential in various industrial applications, including water treatment, enhanced transport processes, and disinfection. However, the feasibility of utilizing MNBs water as a …
Publication
Novel Humanized Aortic Valve Calcification Model
Novel Humanized Aortic Valve Calcification Model …
Publication
Sex differences in middle cerebral artery reactivity and hemodynamics independent from changes in systemic arterial stiffness in Sprague–Dawley rats
The mechanisms of sex differences in cerebrovascular function are not well understood. In this study, we determined whether sex differences in middle cerebral artery (MCA) reactivity are accompanied with changes in cerebral or systemic arterial resistance …
Publication
In Vitro and In Vivo Photothermal and Photoacoustic Activities of Polymeric Nanoparticles Loaded with Nickel, Palladium, and Platinum-Bis(dithiolene) Complexes
The development of nanosystems with enhanced photothermal and photoacoustic properties is crucial for advancing theranostic applications in cancer therapy. This study explores polymeric nanoparticles (NPs) constituted by a biocompatible poly(ethylene …
Publication
Aldosterone-Induced Transformation of Vascular Smooth Muscle Cells into Macrophage-like Cells Participates in Inflammatory Vascular Lesions
Vascular smooth muscle cells (VSMCs) are the most abundant cell type in blood vessels, participating in cardiovascular diseases in various ways, among which their transformation into macrophage-like cells has become a research hotspot. In this study, rats …
Publication
Age‐Dependent Correlation of Pulmonary Function Impairment and Aortic Arch Stiffness in Mice
Progressive aging is known to negatively affect cardiopulmonary function, which increases the risk of developing cardiac/respiratory diseases. However, the relationship between the decline in pulmonary function and aortic arch stiffness in aging is not …
Publication
C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness
Arterial stiffness is a critical factor in cardiovascular and cerebrovascular events, yet clinical practice lacks specific therapeutic targets and biomarkers for its assessment. Hyperlipidemia closely correlates with arterial stiffness, and we observed …
Publication
Development of ultrasound-visualized tumor-targeting engineered bacteria for precise tumor therapy
In situ imaging diagnosis and precise treatment of deep tumor tissues are hotspots in life sciences and medical research. In recent years, using focused ultrasound to remotely control engineered bacteria for drug release has become one of the methods for …