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Publication
Side-Illuminating Optical Fiber for High-Power-Density-Mediated Intraluminal Photoacoustic Imaging
Intraluminal photoacoustic (PA) imaging has the potential for providing physiological and functional information in wide-ranging clinical applications. Along with endoluminal ultrasound transducers, these applications require compact light delivery …
Publication
Dysregulated cholesterol uptake and efflux of bone marrow-derived α-SMA+ macrophages contribute to atherosclerotic plaque formation
Macrophages play differential roles in the pathogenesis of atherosclerosis due to their different phenotypes. Although α-SMA+ macrophages have been found to present in bone marrow and atherosclerotic plaques, their role in atherosclerosis remains unclear. …
Publication
Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity
Obesity, a main driver of cardiovascular morbidity, contributes to endothelial dysfunction and inflammation in adipose tissues. Perivascular adipose tissue (PVAT) surrounds arteries and influences vascular function. In obesity, immune cells, including …
Publication
Ultrasound-Assisted Blood–Brain Barrier Opening Monitoring by Photoacoustic and Fluorescence Imaging Using Indocyanine Green
Objective: The blood–brain barrier (BBB) is a selectively permeable membrane that restricts drug delivery to the central nervous system. Focused ultrasound (FUS) combined with microbubbles (MBs) is a promising technique to transiently open the BBB, …
Publication
Multi-omics analysis of two rat models reveals potential role of vesicle transport and autophagy in right ventricular remodeling
Right ventricular failure as a severe consequence of pulmonary arterial hypertension (PAH) is an independent risk factor for poor prognosis, although the pathogenesis of right ventricular remodeling (RVR) remains unclear. Exploring the shared molecular …
Publication
Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure
End-stage kidney disease (ESKD) impacts over 740,000 individuals in the United States, with many patients relying on arteriovenous fistulae (AVF) for hemodialysis due to superior patency and reduced infections. However, AVF patency is reduced by …
Publication
Botulinum toxin (A)-induced bone loss is associated with increased blood velocity and reduced vascular bone porosity
Disuse-induced bone loss is a common consequence of spaceflight and prolonged bed rest. Intraosseous blood vessel volume and number are decreased in rodents after sciatic nerve resection, and femoral and tibial perfusion and blood flow to the femoral …
Publication
Sympathetic axonogenesis promotes adenoid cystic carcinoma progression
Nerves are integral to the adenoid cystic carcinoma (ACC) microenvironment. The strong association of ACC with perineural invasion (PNI) is considered a hallmark of this disease. In human salivary ACC, we identify intratumoral, small-caliber, disorganized …
Publication
Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations
Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations …
Publication
A Bi2O3-TiO2 Heterojunction for Triple-Modality Cancer Theranostics
Purpose: Owing to the limitations of single-mode cancer treatments, combination therapies have attracted much attention. However, constructing a platform for combination therapies in a simple and effective way and improving the overall treatment effect …