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Publication
Overexpression of miR-22 attenuates oxidative stress injury in diabetic cardiomyopathy via Sirt 1
Background/Aims: Oxidative stress injury is believed to be important in diabetic car- diomyopathy. Recent evidence indicates that miR- 22 plays an important role in vari- ous cardiovascular diseases, but the protective role of miR- 22 in diabetic …
Publication
Suppression of aortic expansion and contractile recovery in a rat abdominal aortic aneurysm model by biodegradable gelatin hydrogel sheet incorporating basic fibroblast growth factor
Biodegradable gelatin hydrogel sheet (BGHS) incorporating basic fibroblast growth factor (bFGF) may inhibit the pro- gression of abdominal aortic aneurysm (AAA). We investigated whether AAA in a rat model treated with BGHS soaked with bFGF can suppress …
Publication
Degradable rhenium trioxide nanocubes with high localized surface plasmon resonance absorbance like gold for photothermal theranostics
The applications of inorganic theranostic agents in clinical trials are generally limited to their innate non-biodegradability and potential long-term biotoxicity. To address this problem, herein via a straightforward and tailored space-confined …
Publication
Changes in the cardiac GHSR1a-ghrelin system correlate with myocardial dysfunction in diabetic cardiomyopathy in mice
Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are present in cardiac tissue. Activation ofGHSR1aby ghrelin promotes cardiomyocyte contractility and survival, and changes in myocardial GHSR1a and circulating ghrelin track …
Publication
Alterations of Ocular Hemodynamics Impair Ophthalmic Vascular and Neuroretinal Function
Hypertension is associated with numerous diseases, but its direct impact on the ocular circulation and neuroretinal function remains unclear. Herein, mouse eyes were challenged with different levels of hemodynamic insult via transverse aortic coarctation, …
Publication
Targeting ALDH2 for therapeutic interventions in chronic pain-related myocardial ischemic susceptibility
Clinical observations have demonstrated a link between chronic pain and increased ischemic heart disease mortality, but the mechanisms remain elusive. Reactive aldehydes have recently been confirmed as a new player in pain pathologies, while our previous …
Publication
Thy1-Targeted Microbubbles for Ultrasound Molecular Imaging of Pancreatic Ductal Adenocarcinoma
Purpose: To engineer a dual human and murine Thy1-binding single-chain-antibody ligand (Thy1-scFv) for contrast microbub- ble–enhanced ultrasound molecular imaging of pancreatic ductal adenocarcinoma (PDAC). Experimental Design:Thy1-scFvwere engineered …
Publication
Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow
Low and disturbed blood flow drives the progression of arterial diseases including atherosclerosis and aneurysms. The endothelial response to flow and its interactions with recruited platelets and leukocytes determine disease progression. Here, we report …
Publication
Pyridostigmine protects against cardiomyopathy associated with adipose tissue browning and improvement of vagal activity in high-fat diet rats
Obesity, a major contributor to the development of cardiovascular diseases, is associated with an autonomic imbalance characterized by sympathetic hyperactivity and diminished vagal activity. Vagal activation plays important roles in weight loss and …
Publication
Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection
Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is …