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Renal Resistive Index as a Novel Indicator for Renal Complications in High-Fat Diet-Fed Mice
Background/Aims: The renal resistive index (RI) is a novel candidate as a renal injury prognostic indicator, but it remains unclear how renal RI levels correspond to renal injury in diabetic nephropathy. Methods: To examine this issue, we compared …
Publication
The intake of red raspberry fruit is inversely related to cardiac risk factors associated with metabolic syndrome
The effect of red raspberry fruit (RSP) was assessed in obesity-prone, Zucker Fatty rats as a model of cardiometabolic risk. RSP reduced fasting triglycerides and fasting glucose but did not appear to affect fasting insulin, low-density lipoprotein, or …
Publication
Tumour vascular shutdown and cell death following ultrasound-microbubble enhanced radiation therapy
High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation …
Publication
Molecularly Engineered Theranostic Nanoparticles for Thrombosed Vessels: H2O2-Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy
A thrombus (blood clot), composed mainly of activated platelets and fibrin, obstructs arteries or veins, leading to various life-threatening diseases. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and an …
Publication
Nanoscale covalent organic polymers as a biodegradable nanomedicine for chemotherapy-enhanced photodynamic therapy of cancer
Recently, covalent-organic polymers (COPs), which covalently cross-link different types of organic molecules to form organic network structures, have received significant attention in various fields. However, the design of COPs that allows them to act as …
Publication
A Theranostic Nanoplatform: Triple-Model Imaging Guided Synergistic Cancer Therapy Based on Liposomes Conjugated Mesoporous Silica Nanoparticles
Mesoporous silica nanoparticles (MSNs) have long since been investigated to provide a versatile drug-delivery platform due to their multitudinous merits. Presently, gadolinium (Gd), a T1 magnetic resonance imaging (MRI) contrast agent, was doped into MSNs …
Publication
Switchable Photoacoustic Intensity of Methylene Blue via Sodium Dodecyl Sulfate Micellization
The interaction between methylene blue (MB) and sodium dodecyl sulfate (SDS) has been widely studied spectroscopically, but details about their interactions remain unclear. Here, we combined photoacoustic (PA) imaging with nanoparticle tracking analysis …
Publication
Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice
Heart failure after myocardial infarction (MI) depends on infarct size and adverse left ventricular (LV) remodelling, both influenced by the inflammatory response. Leukocyte-associated immunoglobulin- like receptor 1 (LAIR-1) is an inhibitory receptor of …
Publication
Qiliqiangxin attenuates isoproterenol-induced cardiac remodeling in mice
Background: To further explore the role of PPARγ in QL treatment, ISO-induced mice model and following methods were established. Methods: Cardiac remodeling on mice model was induced by isoproterenol (ISO) infu- sion or saline infusion as control for two …
Publication
Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload.
OBJECTIVES Mechanical overload can be classified into pressure overload and volume overload, causing concentric and eccentric cardiac hypertrophy, respectively. Here, we aimed to differentiate the load-mediated signaling pathways involved in pressure …