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Nothobranchius furzeri: a vertebrate model for studying cardiac aging and cellular senescence
African turquoise killifish (Nothobranchius furzeri) is the shortest-lived vertebrate that can be bred in captivity, making it an ideal model organism for aging studies. However, whether the animal can be used for studying cardiac aging and whether …
Publication
Injured tubule derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis
Epidemiological studies show that heart failure often leads to kidney dysfunction, known as cardio-renal syndrome (CRS). Elevated central venous pressure, rather than low cardiac output, strongly correlates with worsening renal function and is …
Publication
SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2
Activating mutations of Src homology-2 domain-containing protein tyrosine phosphatase-2 (Shp2) cause multiple childhood conditions for which there is an unmet therapeutic need, including juvenile myelomonocytic leukemia (JMML) and Noonan syndrome. SFX-01, …
Publication
Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression
Macrophage pyroptosis has been identified as a critical pathological mechanism in inflammation-related athero-sclerosis (AS). In this work, we have demonstrated that Zn 2+ features the strongest anti-inflammatory performance by screening 10 representative …
Publication
Designing a Sulfur Vacancy Redox Disruptor for Photothermoelectric and Cascade-Catalytic-Driven Cuproptosis–Ferroptosis–Apoptosis Therapy
The glycometabolism and enzyme activity of Cu2MnS3-x-PEG/glucose oxidase (MCPG) achieve a cascade catalytic reaction, continuously replenishing the deficient H2O2 and O2 and inducing adequate reactive oxygen species supply. Density functional theory …
Publication
Intravesical VSVd51-GM-CSF virotherapy is superior to BCG in treating bladder cancer in preclinical and translational models
Non-muscle-invasive bladder cancer (NMIBC) can progress to muscle-invasive disease, with transurethral resection followed by Bacillus Calmette-Guérin (BCG) immunotherapy reducing this risk. Effective immunotherapies for BCG-resistant NMIBC are lacking. …
Publication
Toll like receptor 2 mediated exacerbation of sepsis associated acute kidney injury by renal congestion in mice
Renal congestion is a key factor in renal dysfunction associated with heart failure. We previously reported that renal congestion worsened renal ischemia-reperfusion in a murine model. However, its impact on sepsis-associated acute kidney injury (SA-AKI), …
Publication
Antitumoral Efficacy of AuNRs-Laden ECFCs In Vitro and In Vivo: Decoding the Heat and Rays Combo Treatment in Breast Cancer and Melanoma Cells
Radiotherapy remains a cornerstone in metastatic cancer treatment but is often hindered by tumor hypoxia and radioresistance. Gold nanorods (AuNRs) offer promise in enhancing radiotherapy through hyperthermia, yet their clinical impact is limited by poor …
Publication
Depth-dependent fluence compensation without a priori knowledge of tissue composition for quantitative ultrasound-guided photoacoustic imaging
Depth-dependent fluence compensation without a priori knowledge of tissue composition for quantitative ultrasound-guided photoacoustic …
Publication
The angiotensin II type 2 receptor attenuates aging-associated arterial stiffness in female mice
This is the first investigation to show that the angiotensin II type 2 receptor (AT2R) attenuates aging-associated arterial stiffness in middle-aged female mice. The AT2R also attenuates arterial stiffness in young female and male mice, but there are …