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Nanobubbles based on repeated compression for contrast-enhanced ultrasound (CEUS) imaging of renal fibrosis
Renal fibrosis, a crucial pathological process in chronic kidney disease, requires early precise diagnosis to delay renal failure. Traditional ultrasound has limitations in sensitivity and specificity. In this study, SF 6 -loaded phospholipid nanobubbles …
Publication
Extending the transmit and receive bandwidths of dual-frequency transducers towards clinical acoustic angiography: in vitro and in vivo studies
Extending the transmit and receive bandwidths of dual-frequency transducers towards clinical acoustic angiography: in vitro and in vivo …
Publication
Impact of low nitrate/nitrite diet and nitrate supplementation on litter size and fetal and placental growth in pregnant mice
Background: In pregnancy, nitric oxide (NO) plays important roles in embryo development, maternal cardiovascular function, fetoplacental blood flow and fetal growth. Whilst the importance of NO synthase (NOS)-derived NO has been studied in pregnancy, …
Publication
MicroRNA-15a-5p mediates abdominal aortic aneurysm progression and serves as a potential diagnostic and prognostic circulating biomarker
Background: MicroRNAs are post transcriptional modulators of gene expression. We explored the diagnostic and prognostic value of circulating microRNAs in abdominal aortic aneurysm (AAA) disease, for which currently no established circulating biomarker is …
Publication
Ultrasound-Triggered NPC1L1-Targeting Nanobubbles for Remodeling the Tumor Microenvironment in Pancreatic Cancer Chemoimmunotherapy
Abnormal cholesterol metabolism promotes the immunosuppressive microenvironment of pancreatic cancer and affects the long-term efficacy of chemotherapy drugs. Accurate diagnosis and targeted microenvironment-remodeling are challenging during the …
Publication
Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human
Background: Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are conducted in animal models. To date, …
Publication
Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers
Background: Near-infrared fluorescence (NIRF) imaging assists surgeons intraoperatively to achieve radical resection of malignant tissue with one centimeter depth and can be supplemented with photoacoustic imaging to increase depth-of-view. …
Publication
GPA33-pretargeted radioimmunotherapy with mono- and bivalent DOTA-based Lu-177-labeled radiohaptens in a mouse orthotopic liver xenograft model of metastatic human colorectal cancer
Rationale: Pretargeted radioimmunotherapy (PRIT), which combines systemic antibody-based targeting with ionizing radiation, is promising for treating liver metastases in patients with colorectal cancer (CRC). Previously, we established a three-step …
Publication
Genetically engineered bio-composite mediated dual-modality imaging-guided synergistic chemo-FUAS for tumor therapy
Focused ultrasound ablation surgery (FUAS) combined with bacterial synergistic therapy has significant potential in solid tumors, however, this combination therapy has been limited mainly due to its weak anti-tumor effects, single imaging modality, and …
Publication
Multimodal Imaging of Brain Metastasis-Derived Extracellular Vesicles Using Superparamagnetic Iron Oxide Nanoparticle Labeling
Background: Extracellular vesicles (EVs) are crucial mediators in brain metastasis (BM), facilitating pre-metastatic niche formation and metastatic progression. However, tracking their distribution and interactions in vivo remains challenging. Objective: …