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The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function
ANKRD11 (Ankyrin Repeat Domain 11) is a chromatin regulator and a causative gene for KBG syndrome, a rare developmental disorder characterized by multiple organ abnormalities, including cardiac defects. However, the role of ANKRD11 in heart development is …
Publication
Dual-Drug Nanomedicine Assembly with Synergistic Anti-Aneurysmal Effects via Inflammation Suppression and Extracellular Matrix Stabilization
Abdominal aortic aneurysm (AAA) represents a critical cardiovascular condition characterized by localized dilation of the abdominal aorta, carrying a significant risk of rupture and mortality. Current treatment options are limited, necessitating novel …
Publication
Ultra-high-frequency ultrasound (48–70 MHz) is a promising tool for improved gastrointestinal diagnostics in infants
Aim: To investigate the clinical feasibility of ultra-high-frequency abdominal ultrasound (UHFUS) scans of preterm and term infants. Methods: Prospectively, 19 healthy term newborn infants were examined with conventional ultrasound (CUS) (Toshiba, Aplio …
Publication
A lung cancer mouse model system based on an inbred C3H strain: Ultrasound imaging, pathological analysis, and proteomic biomarker identification
Background and Aim: Lung cancer remains a leading cause of global mortality, necessitating robust animal models for research into its mechanisms and therapeutic options. This study aimed to develop and validate a novel lung cancer mouse model using the …
Publication
PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling
Background: Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo Serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several tumors. Specifically, PHGDH expression is dynamically regulated during …
Publication
In Vivo Dynamic Coronary Arteries Blood Flow Imaging Based on Multi-Cycle Phase Clustering Ultrafast Ultrasound
Echocardiography is the most primary clinical modality for dynamic cardiac imaging. However, the vigorous motion of myocardial tissue inherently causes inevitable signal aliasing between blood flow and myocardial tissue in traditional Doppler ultrasound …
Publication
An SRRM3-regulated neural alternative splicing program is subverted to promote tumor progression in pancreatic neuroendocrine cells
An SRRM3-regulated neural alternative splicing program is subverted to promote tumor progression in pancreatic neuroendocrine cells …
Publication
Mechanistic insight into plasticizer di-(2-ethylhexyl) phthalate as an environmental hazard for abdominal aortic aneurysm: Evidence from in vitro and in vivo studies
Mechanistic insight into plasticizer di-(2-ethylhexyl) phthalate as an environmental hazard for abdominal aortic aneurysm: Evidence from in vitro and in vivo …
Publication
BCAA catabolism targeted therapy for heart failure with preserved ejection fraction
BCAA catabolism targeted therapy for heart failure with preserved ejection fraction …
Publication
The effect of presence and location of microcalcifications on atherosclerotic plaque rupture: A tissue-engineering approach
The effect of presence and location of microcalcifications on atherosclerotic plaque rupture: A tissue-engineering approach …