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Krox20 heterozygous mice: A model of aortic regurgitation associated with decreased expression of fibrillar collagen genes
Abstract BACKGROUND: The mechanism involved in the onset of aortic valve (AoV) disease remains unclear despite its poor prognosis and frequency. Recently, we reported that Krox20 (EGR2 in humans) is involved in AoV development and dysfunction. AIM: …
Publication
Inhibition of late Na + current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats
Late Na current (INaL) is enhanced in myocytes of animals with chronic heart failure and patients with hypertrophic cardiomyopathy. To define the role of INaL in diastolic heart failure, the effects of GS-458967 (GS-967), a potent INaL inhibitor on …
Publication
Tumor priming using metronomic chemotherapy with neovasculature-targeted, Nanoparticulate paclitaxel
Normalization of the tumor microenvironment is a promising approach to render conventional chemotherapy more effective. Although passively targeted drug nanocarriers have been investigated to this end, actively targeted tumor priming remains to be …
Publication
Follistatin‐like 1 promotes cardiac fibroblast activation and protects the heart from rupture
Follistatin-like 1 (Fstl1) is a secreted protein that is acutely induced in heart following myocardial infarction (MI). In this study, we investigated cell type-specific regulation of Fstl1 and its function in a murine model of MI. Fstl1 was robustly …
Publication
Splenic release of platelets contributes to increased circulating platelet size and inflammation after myocardial infarction
Acute myocardial infarction (AMI) is characterized by a rapid increase in circulating platelet size but the mechanism for this is unclear. Large platelets are hyperactive and associated with adverse clinical outcomes. We determined mean platelet volume …
Publication
Exercise Prevents Diet-induced Cellular Senescence in Adipose Tissue
Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, the extent to which they affect the behavior and accretion of senescent cells within distinct …
Publication
Naturally occurring p16 Ink4a -positive cells shorten healthy lifespan
0 0 M o n t h 2 0 1 6 | V o L 0 0 0 | n A t U R E | 1 Cellular senescence is a well-established cancer defence mechanism that has also been proposed to have roles in ageing and age-associated diseases, presumably through the depletion of stem and …
Publication
Nanotherapy silencing the interleukin-8 gene produces regression of prostate cancer by inhibition of angiogenesis
Interleukin-8 (IL-8) is a proangiogenic cytokine associated with aggressive prostate cancer (CaP). We detected high levels of IL-8 in sera from patients with CaP compared to healthy controls and patients with benign prostatic hypertrophy. This study …
Publication
Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess
Fetoplacental glucocorticoid overexposure is a significant mecha- nism underlying fetal growth restriction and the programming of adverse health outcomes in the adult. Placental glucocorticoid inactivation by 11β-hydroxysteroid dehydrogenase type 2 (11β- …
Publication
High-resolution renal perfusion mapping using contrast-enhanced ultrasonography in ischemia-reperfusion injury monitors changes in renal microperfusion
Alterations in renal microperfusion play an important role in the development of acute kidney injury with long- term consequences. Here we used contrast-enhanced ultrasonography as a novel method for depicting intrarenal distribution of blood flow. After …