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Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury
Myocardial infarction results in compromised myocardial function and heart failure owing to insufficient cardiomyocyte self-renewal1. Unlike many vertebrates, mammalian hearts have only a transient neonatal renewal capacity2. Reactivating primitive …
Publication
Human Chorionic Gonadotropin Has Anti-Inflammatory Effects at the Maternal-Fetal Interface and Prevents Endotoxin-Induced Preterm Birth, but Causes Dystocia and Fetal Compromise in Mice
Human chorionic gonadotropin (hCG) is implicated in the maintenance of uterine quiescence by down-regulating myometrial gap junctions during pregnancy, and it was considered as a strategy to prevent preterm birth after the occurrence of preterm labor. …
Publication
Novel effects of simvastatin on uterine fibroid tumors: In vitro and patient-derived xenograft mouse model study
Objective Uterine leiomyomas represent a common gynecologic problem with no satisfactory long-term medical treatment. The purpose of this study is to examine the effects of simvastatin on uterine leiomyoma, both in vitro and in vivo. Study Design This is …
Publication
Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice
Cerebral ischemia is a significant source of morbidity in children with sickle cell anemia; however, the mechanism of injury is poorly understood. Increased cerebral blood flow and low hemoglobin levels in children with sickle cell anemia are associated …
Publication
LOW-MAGNITUDE HIGH-FREQUENCY VIBRATION ENHANCED MESENCHYMAL STEM CELL RECRUITMENT IN OSTEOPOROTIC FRACTURE HEALING THROUGH THE SDF-1 / CXCR4 PATHWAY
Low-magnitude high-frequency vibration (LMHFV) has been proven to promote osteoporotic fracture healing. Mechanical stimulation was reported to enhance SDF-1/ CXCR4 signalling in mesenchymal stem cells (MSCs). We hypothesised that LMHFV promoted …
Publication
Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies
The efficiency of assisted reproductive technologies (ARTs) in nonhuman primates is low due to no screening criterions for selecting sperm, oocyte, and embryo as well as its surrogate mothers. Here we analyzed 15 pairs of pregnant and non-pregnant …
Publication
Intratendinous Injection of Hyaluronate Induces Acute Inflammation: A Possible Detrimental Effect
Abstract Hyaluronate (HA) is therapeutic for tendinopathy, but an intratendinous HA injection is usu- ally painful; thus, it is not suggested for clinical practice. However, there are no studies on the histopathological changes after an intratendinous HA …
Publication
Monitoring the Growth of an Orthotopic Tumour Xenograft Model: Multi-Modal Imaging Assessment with Benchtop MRI (1T), High-Field MRI (9.4T), Ultrasound and Bioluminescence
Background: Research using orthotopic and transgenicmodels of cancer requires imaging methods to non-invasively quantify tumour burden. As the choice of appropriate imaging modality is wide-ranging, this study aimed to compare low-field (1T) magnetic …
Publication
Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare disease of the pulmonary vasculature characterized by endothelial cell apoptosis, smooth muscle proliferation and obliteration of pulmonary arterioles. This in turn results in right ventricular (RV) failure, …
Publication
Effects of 1, 25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice
BACKGROUND/AIMS: Myocarditis is an important inflammatory disease of the heart which causes life-threatening conditions. 1, 25(OH)2 D3 has effects on multiple systems and diseases. The present study was aimed to investigate the effect of 1, 25(OH)2 D3 on …