Photoacoustic imaging provides high-resolution images at depths beyond the optical diffusion limit. To broaden its utility, there is need for molecular sensors capable of detecting environmental stimuli through alterations in photoacoustic signal. …

Despite the effort of developing various nanodelivery systems, most of them suffer from undesired high uptakes by the reticuloendothelial system, such as liver and spleen. Herein we develop an endogenous phosphatase-triggered coassembly strategy to form …

In this work, we utilized photoacoustic imaging (PAI) with co- registered ultrasound (US) to non-invasively assess salivary gland function in vivo. A significant increase in salivary gland oxygen saturation was observed on PAI within minutes after …

Objective . Sentinel node biopsy in patients with cutaneous melanoma improves staging, provides prognostic information, and leads to an increased survival in node-positive patients. However, frozen section analysis of the sentinel node is not reliable and …

Photoacoustic imaging combines the high contrast of optical imaging with the spatial resolution and penetration depth of ultrasound. This technique holds tremendous potential for imaging in small animals and importantly, is clinically translatable. At …

Preclinical, noninvasive imaging of tissue engineering polymeric scaffold structure and/or the physiological processes such as blood oxygenation remains a challenge. In vitro or ex vivo, the widely used scaffold characterization modalities such as …

Metastases rather than primary tumors are responsible for killing most patients with cancer. Cancer cells often invade regional lymph nodes (LN) before colonizing other parts of the body. However, due to the low sensitivity and specificity of current …

Photoacoustic imaging has evolved into a clinically translatable platform with the potential to complement existing imaging techniques for the management of cancer, including detection, characterization, prognosis, and treatment monitoring. In …

In utero exposure of rat embryos to dimethadione (DMO), the N-demethylated teratogenic metabolite of the anticonvulsant trimethadione, induces a high incidence of cardiac heart defects including ventricular septal defects (VSDs). The same exposure regimen …

Recent development of ultra high-resolution ultrasound systems, with frequencies as high as 70 MHz and capabil- ity resolution as fine as 30 lm, could permit new diagnostic applications to small parts. A variety of superficial targets within the first 1 …