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Microbubble composition and preparation for high-frequency contrast-enhanced ultrasound imaging: in vitro and in vivo evaluation
Although high-frequency ultrasound imaging is gaining attention in various applications, hardly any ultrasound contrast agents (UCAs) dedicated to such frequencies (> 15 MHz) are available for contrast-enhanced ultrasound imaging (CEUS). Moreover, the …
Publication
Bariatric Surgery Ameliorates Diabetic Cardiac Dysfunction by Inhibiting ER Stress in a Diabetic Rat Model
Background Cardiac dysfunction is a severe complication of diabetes,with no effective treatment.Currently, bariatric surgery is moreandmorewidelyusedtoattenuate diabetes-associated diseases. The mechanism is not clear. Endoplasmic reticulum (ER) …
Publication
The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility
Several erythropoietin-producing hepatocellular receptor B family (EPHB) and their ligands, ephrinBs (EFNBs), are involved in blood pressure regulation in animal models. We selected 528 single nucleotide polymorphisms (SNPs) within the genes of EPHB6, …
Publication
Female Mice With an XY Sex Chromosome Complement Develop Severe Angiotensin II–Induced Abdominal Aortic AneurysmsClinical Perspective
Background—Abdominal aortic aneurysms (AAAs) are a deadly pathology with strong sexual dimorphism. Similar to humans, female mice exhibit far lower incidences of angiotensin II (AngII)-induced AAAs than males. In addition to sex hormones, the X and Y sex …
Publication
Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice
Background: T2DM is a high-risk pregnancy with adverse fetal and maternal outcomes including repeated miscar- riages and fetal malformations. Despite the established association between placental insufficiency and poor mater- nal Th1-adaptability to the …
Publication
UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity
Doxorubicin (DOX) is an effective chemotherapeutic drug in the treatment of various types of cancers. However, its clinical application has been largely limited by potential development of cardiotoxicity. Previously we have shown that ultra-violet …
Publication
Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction
Inflammation is a known mediator of adverse ventricular remodeling aftermyocardial infarction (MI) thatmay lead to reduction of ejection fraction and subsequent heart failure. Berberine is a isoquinoline quarternary alka- loid from plants that has been …
Publication
Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc -deficient mice
OBJECTIVE We used non-invasive high frequency ultrasound (HFUS) imaging to investigate embryonic brain development in a mouse model for neural tube defects (NTDs) and Non-Ketotic Hyperglycinemia (NKH). METHOD Using HFUS, we imaged embryos carrying loss of …
Publication
Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc -deficient mice
OBJECTIVE We used non-invasive high frequency ultrasound (HFUS) imaging to investigate embryonic brain development in a mouse model for neural tube defects (NTDs) and Non-Ketotic Hyperglycinemia (NKH). METHOD Using HFUS, we imaged embryos carrying loss of …